IFN-γ(g)uarding the niche-Keeping ILC2 in check

The causal signals and the relevance of group 2 innate lymphoid cell (ILC2) dynamic redistribution during inflammation remain unknown. In this issue of Immunity, Cautivo et al. show that type 2 immunity drives ILC2 accumulation at non-adventitial parenchymal'' sites, allowing balanced responses in inflamed tissues.

Automated summary

This study reveals the importance of type 2 immunity in driving the accumulation of ILC2 in inflamed tissues, allowing for balanced responses during inflammation.