4.7 Article

COVID-view: Diagnosis of COVID-19 using Chest CT

Journal

Publisher

IEEE COMPUTER SOC
DOI: 10.1109/TVCG.2021.3114851

Keywords

COVID-19; Lung; Computed tomography; Visualization; Three-dimensional displays; Solid modeling; Lesions; visual-deep learning diagnosis; COVID-19; chest CT; volume rendering; MIP; classification model; explainable DL

Funding

  1. NSF [CNS1650499, OAC1919752, ICER1940302, IIS2107224]
  2. OVPR-IEDM COVID-19 grant

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Significant progress has been made in the development of deep learning models for automatic lung and lesion segmentation and classification of COVID-19 on chest CT data. However, there is currently a lack of comprehensive visualization systems that support the dual visual and deep learning diagnosis of COVID-19. In this study, the authors present COVID-view, a visualization application designed specifically for radiologists to diagnose COVID-19 from chest CT data. The system incorporates a complete pipeline of automatic lung segmentation, abnormality localization, visualization, and deep learning analysis, providing radiologists with a more comprehensive diagnostic tool.
Significant work has been done towards deep learning (DL) models for automatic lung and lesion segmentation and classification of COVID-19 on chest CT data. However, comprehensive visualization systems focused on supporting the dual visual+DL diagnosis of COVID-19 are non-existent. We present COVID-view, a visualization application specially tailored for radiologists to diagnose COVID-19 from chest CT data. The system incorporates a complete pipeline of automatic lungs segmentation, localization/isolation of lung abnormalities, followed by visualization, visual and DL analysis, and measurement/quantification tools. Our system combines the traditional 2D workflow of radiologists with newer 2D and 3D visualization techniques with DL support for a more comprehensive diagnosis. COVID-view incorporates a novel DL model for classifying the patients into positive/negative COVID-19 cases, which acts as a reading aid for the radiologist using COVID-view and provides the attention heatmap as an explainable DL for the model output. We designed and evaluated COVID-view through suggestions, close feedback and conducting case studies of real-world patient data by expert radiologists who have substantial experience diagnosing chest CT scans for COVID-19, pulmonary embolism, and other forms of lung infections. We present requirements and task analysis for the diagnosis of COVID-19 that motivate our design choices and results in a practical system which is capable of handling real-world patient cases.

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