4.7 Article

On Hallucinations in Tomographic Image Reconstruction

Journal

IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 40, Issue 11, Pages 3249-3260

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2021.3077857

Keywords

Image reconstruction; Imaging; Reconstruction algorithms; Noise measurement; Training; Null space; Superresolution; Tomographic image reconstruction; image quality assessment; deep learning; hallucinations

Funding

  1. National Institutes of Health (NIH) [EB020604, EB023045, NS102213, EB028652]
  2. National Science Foundation (NSF) [DMS1614305]

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This study explores the use of deep neural networks to learn prior information for image reconstruction and their ability to generalize to data outside the training distribution. Inaccurate priors may lead to false structures in the reconstructed image, and the concept of a hallucination map is introduced to understand the impact of prior in regularized reconstruction methods. The behavior of different reconstruction methods is discussed based on numerical studies in a stylized tomographic imaging modality.
Tomographic image reconstruction is generally an ill-posed linear inverse problem. Such ill-posed inverse problems are typically regularized using prior knowledge of the sought-after object property. Recently, deep neural networks have been actively investigated for regularizing image reconstruction problems by learning a prior for the object properties from training images. However, an analysis of the prior information learned by these deep networks and their ability to generalize to data that may lie outside the training distribution is still being explored. An inaccurate prior might lead to false structures being hallucinated in the reconstructed image and that is a cause for serious concern in medical imaging. In this work, we propose to illustrate the effect of the prior imposed by a reconstruction method by decomposing the image estimate into generalized measurement and null components. The concept of a hallucination map is introduced for the general purpose of understanding the effect of the prior in regularized reconstruction methods. Numerical studies are conducted corresponding to a stylized tomographic imaging modality. The behavior of different reconstruction methods under the proposed formalism is discussed with the help of the numerical studies.

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