Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 159, Issue 4, Pages 427-430Publisher
SPRINGER
DOI: 10.1007/s10517-015-2982-x
Keywords
17 beta-estradiol; isolated arteries; hypoxic pulmonary hypertension; acetylcholine; female rats
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The long-term (4 weeks) administration of estradiol (15 mu g/kg/day) to ovariectomized female Wistar rats induced hypoxic pulmonary hypertension and significantly (p < 0.05) diminished relaxation of perfused serotonin-preconstricted isolated vascular segments of the pulmonary artery in response to estradiol (10(-6) M). At the same time, the isolated segments of systemic popliteal artery demonstrated a diminished response to serotonin and increased relaxation induced by acetylcholine (10(-5) M) or estradiol (10(-5) M) in comparison with preconstricted control vessels. Moderation of responsiveness to estradiol in pulmonary circulation can be one of the factors underlying the pro-hypertensive action of estradiol in female rats with hypoxic pulmonary hypertension.
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