4.6 Article

Laparoscopic Probe for Sentinel Lymph Node Harvesting Using Magnetic Nanoparticles

Journal

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 69, Issue 1, Pages 286-293

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2021.3092437

Keywords

Magnetometers; Magnetic resonance imaging; Probes; Magnetic separation; Magnetosphere; Laparoscopes; Lymph nodes; Laparoscopic differential magnetometer; laparoscopic surgery; magnetic detection; magnetic nanoparticle; sentinel lymph node; SPION

Funding

  1. Netherlands Organization for scientific Research (NWO), under the research program Magnetic Sensing for Laparoscopy (MagLap) [14322]

Ask authors/readers for more resources

This study reports a new laparoscopic technique for lymph node harvesting using magnetic nanoparticles, and evaluates its clinical relevance and potential for further technological development.
Objective: Sentinel lymph node harvesting is an essential step in the surgical treatment of a growing number of malignancies. Various techniques are available to facilitate this purpose. The present study reports a new laparoscopic technique for lymph node harvesting using magnetic nanoparticles containing a superparamagnetic iron-oxide core and dextran coating. This study assesses the clinical relevance of the prototype and provides input for further technological development on the way to clinical implementation. Methods: A laparoscopic differential magnetometer prototype was built, utilizing a nonlinear detection principle (differential magnetometry) for magnetic identification of lymph nodes. The iron content sensitivity, depth & spatial sensitivity, and angular sensitivity were analyzed to investigate clinical options. Results: The minimum detectable amount of iron was 9.8 mu g at a distance of 1 mm. The detection depth was 5, 8, and 10 mm for samples containing 126, 252, and 504 mu g iron, respectively. The maximum lateral detection distance was 5, 7, and 8 mm for samples containing 126, 252, and 504 mu g iron, respectively. A sample containing 504 mu g iron was detectable at all angulations assessed (0 degrees, 30 degrees, 60 degrees and 90 degrees). Conclusion: The laparoscopic differential magnetometer demonstrates promising results for further investigation and development towards laparoscopic lymph node harvesting using magnetic nanoparticles. Significance: The laparoscopic differential magnetometer facilitates a novel method for sentinel lymph node harvesting, which helps to determine prognosis and treatment of cancer patients.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available