Journal
IEEE SENSORS JOURNAL
Volume 22, Issue 7, Pages 6593-6600Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2022.3148285
Keywords
Gold nanoparticles; graphene oxide; localized surface plasmon resonance; optical fiber sensor; immunoassay
Funding
- Ministry of Science and Technology [109WFA2610187]
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This study presents the development of a localized surface plasmon resonance (LSPR) based optical fiber biosensor. The sensitivity of the sensor is improved by modifying the surface of fiber probes with gold nanoparticles (AuNPs) and graphene oxide (GO) to form a nanocomposite film. The immobilized fiber probes exhibit quicker reaction and larger resonant wavelength shift compared to the AuNPs fiber probe. In addition, the GO/AuNPs fiber probe shows better sensitivity, linearity, and a lower limit of detection in a low concentration of mouse IgG detection.
In this study, the development of a reflected-type localized surface plasmon resonance (LSPR) based optical fiber biosensor is presented. The gold nanoparticles (AuNPs) and graphene oxide (GO) are sequentially modified on the surface of fiber probes to form a nanocomposite film using self-assembly method. Compared with AuNPs fiber probe, the refractive index sensitivity (RIS) of GO/AuNPs fiber probe is improved from 29.6 nm/RIU to 79 nm/RIU in the refractive index range from 1.33 to 1.38. After that, the fiber probes are immobilized with anti-mouse IgG for the immunoassay, and the response time is 30 minutes. Due to the advantages of good biocompatibility as well as physical and optical properties of GO, the GO/AuNPs fiber probe shows a quicker reaction and larger resonant wavelength shift, which are compared with AuNPs fiber probe in measuring different concentrations of mouse IgG. In addition, the GO/AuNPs fiber probe exhibits a better sensitivity (150.4 nm/mu g mL(-1)), linearity (R-2 = 0.998) and a lower limit of detection (4.3 ng/mL) in a low concentration of mouse IgG detection, which suggests that GO has huge potentials of biosensing applications in the future.
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