Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 159, Issue 1, Pages 138-141Publisher
SPRINGER
DOI: 10.1007/s10517-015-2909-6
Keywords
apoptotic bodies; resident stem cells; myocardial regeneration; chronic heart failure
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Funding
- Russian Foundation for Basic Research [1-04-00993a]
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Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart.
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