Emerging Insights Into Chronic Renal Disease Pathogenesis in Hypertension From Human and Animal Genomic Studies

The pathogenic links between elevated blood pressure and chronic kidney disease remain obscure. This article examines progress in population genetics and in animal models of hypertension and chronic kidney disease. It also provides a critique of the application of genome-wide association studies to understanding the heritability of renal function. Emerging themes identified indicate that heritable risk of chronic kidney disease in hypertension can arise from genetic variation in (1) glomerular and tubular protein handling mechanisms; (2) autoregulatory capacity of the renal vasculature; and (3) innate and adaptive immune mechanisms. Increased prevalence of hypertension-associated chronic kidney disease that occurs with aging may reflect amplification of heritable risks by normal aging processes affecting immunity and autoregulation.

Automated summary

This article explores the unclear connections between elevated blood pressure and chronic kidney disease, focusing on genetic variations in protein handling mechanisms, renal vasculature autoregulation, and immune mechanisms as potential heritable risk factors. Additionally, it critiques the application of genome-wide association studies to understanding the heritability of renal function in hypertension-related chronic kidney disease.