Journal
HUMAN BRAIN MAPPING
Volume 43, Issue 8, Pages 2495-2502Publisher
WILEY
DOI: 10.1002/hbm.25798
Keywords
attention-deficit hyperactivity disorder; brain; iron; magnetic resonance imaging; quantitative susceptibility mapping
Funding
- Chongqing Municipal Education Commission [KJQN202000425]
- National Clinical Research Center for Child Health and Disorders [NCRCCHD-2021-YP-07]
- GE Healthcare
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This study investigated the feasibility of using quantitative susceptibility mapping to examine the iron content in the brains of children with attention-deficit hyperactivity disorder (ADHD). The results showed that children with ADHD had lower iron content in certain brain regions compared to healthy children, and their frontal lobe and hippocampus were smaller in volume.
To investigate the feasibility of quantitative susceptibility mapping in children with attention-deficit hyperactivity disorder (ADHD), 53 children with ADHD aged 5-16 years were prospectively selected as the study group and 49 healthy children matched with age and gender were selected as the control group. All children underwent magnetic resonance imaging conventional sequence, 3D-T1, and enhanced T2*-weighted magnetic resonance angiography (ESWAN) sequence scanning. The iron content of brain regions was obtained through software postprocessing, and the iron content of brain regions of children with ADHD and healthy children was compared and analyzed to find out the characteristics of the iron content of brain regions of children with ADHD. The iron content in frontal lobe, globus pallidus, caudate nucleus, substantia nigra, putamen, and hippocampus of children with ADHD was lower than that of healthy children (p < .05). There was no significant difference in the content of iron in the left and right brain regions of children with ADHD (p > .05). The volume of frontal lobe and hippocampus of children with ADHD was lower than that of healthy children (p < .05). Iron content in brain areas such as globus pallidus, caudate nucleus, hippocampus, and putamen could distinguish children with ADHD (Area under curve [AUC] > 0.5, p < .05). Quantitative susceptibility mapping showed decreased iron content in some brain regions of children with ADHD.
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