Journal
HUMAN & EXPERIMENTAL TOXICOLOGY
Volume 40, Issue 12_SUPPL, Pages S460-S474Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/09603271211045948
Keywords
Type 2 diabetes; oxidative stress; inflammation; apoptosis; fibrosis; heart and mice
Categories
Funding
- First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine [24587]
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The study showed that Scutellarin can attenuate diabetes-induced cardiac injury by reducing hyperglycemia, weight loss, hyperlipidemia, cardiac damage, oxidative stress, inflammation, and apoptosis. This protective effect is associated with modulation of Nrf2/Keap1 pathway, TLR4/MyD88/NF-kappa B mediated inflammatory pathway, and intrinsic (mitochondrial) apoptosis pathway.
Background Diabetes is a serious global health concern which severely affected public health as well as socio-economic growth worldwide. Scutellarin (SCU), a bioactive flavonoid, is known for its efficacious action against a range of ailments including cardiovascular problems. The present study was conducted to find out possible protective effect and its associated mechanisms of SCU on experimental type 2 diabetes-induced cardiac injury. Methods Type 2 diabetes was induced by treating animals with high fat diet for 4 weeks and a single intraperitoneal dose (35 mg/kg body weight) of streptozotocin and diabetic animals received SCU (10 or 20 mg/kg/day) for 6 weeks. Results Scutellarin attenuated type 2 diabetes-induced hyperglycemia, bodyweight loss, hyperlipidaemia, cardiac functional damage with histopathological alterations and fibrosis. Scutellarin treatment to type 2 diabetic mice ameliorated oxidative stress, inflammatory status and apoptosis in heart. Furthermore, the underlying mechanisms for such mitigation of oxidative stress, inflammation and apoptosis in heart involved modulation of Nrf2/Keap1 pathway, TLR4/MyD88/NF-kappa B mediated inflammatory pathway and intrinsic (mitochondrial) apoptosis pathway, respectively. Conclusions The current findings suggest that SCU is effective in protecting type 2 diabetes-induced cardiac injury by attenuating oxidative stress and inflammatory responses and apoptosis, and it is also worth considering the efficacious potential of SCU to treat diabetic cardiomyopathy patients.
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