Journal
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
Volume 21, Issue 2, Pages 317-322Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s42000-021-00344-9
Keywords
Autoimmune polyglandular syndrome type II; HLA; Hypothyroidism; Autoimmunity; Addison's disease; Diabetes
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Funding
- Kirsten and Freddy Johansen's Foundation
- Copenhagen University Hospital (Rigshospitalet)
- Musikforlaeggerne Agnes and Knut Mork's Foundation
- Desiree and Niels Yde's Foundation
- Danish Medical Association's Research Foundation
- A.P. Moller Foundation for the Advancement of Medical Science
- Danish Thyroid Patient Association
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This article reports a case of autoimmune polyglandular syndrome type II (APS II) in a patient who was initially diagnosed with hypothyroidism and presented with fatigue and rapid weight loss. Through examinations and genetic sequencing, the final diagnoses included Hashimoto's thyroiditis, Addison's disease, vitiligo, and pernicious anemia. The findings suggest that awareness of potential polyautoimmunity in patients with thyroid disease can improve diagnosis and even be life-saving.
Background Autoimmune disease, including autoimmune thyroid disease, with uncharacteristic symptoms can be due to additional severe disease. We report a life-threatening debut of autoimmune polyglandular syndrome type II (APS II) defined as Addison's disease combined with autoimmune diabetes and/or thyroid disease. Patient findings A 33-year-old male with newly diagnosed hypothyroidism was referred to a tertiary center due to fatigue and 20-kg rapid weight loss. Malignancy was excluded. After a gastroscopy, he developed Addison's crisis; he was admitted to our hospital and stabilized. Final diagnoses included Hashimoto's thyroiditis, Addison's disease, vitiligo, and pernicious anemia. Whole genome sequencing found no genetic variants associated with component diseases. Human leukocyte antigen typing revealed DR3/DR4 and DQ8/DQ2 heterozygosity associated with APS II. A patient with Hashimoto's thyroiditis and weight loss presented with Addison's crisis and was diagnosed with APS II. Conclusions Awareness of potential polyautoimmunity in clinical evaluation of patients with thyroid disease improves diagnosis and can be lifesaving.
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