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Article
Gastroenterology & Hepatology
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Summary: Our study demonstrates that specific lipid metabolic pathways are coherently altered when hepatocytes switch to proliferation, providing potential targets for therapeutic strategies and prognostic biomarkers of HCC. By integrating metabolomics, lipidomics, and transcriptomics, we have linked changes in the lipidome of proliferating hepatocytes to altered metabolic pathways including lipogenesis and generation of phosphatidylcholine. Additionally, we confirmed this altered lipid signature in human HCC and found a positive correlation of monounsaturated phosphatidylcholine with hallmarks of cell proliferation and hepatic carcinogenesis.
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Review
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