Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 35, Issue 8, Pages 1903-1906Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2016.2528284
Keywords
Photoacoustic imaging; skull optical clearing solution
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Funding
- National Major Scientific Research Program of China [2011CB910401]
- Science Fund for Creative Research Group of China [61121004]
- National Natural Science Foundation of China [81201067, 81171376, 91232710, 812111313]
- WNLO
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The performance of photoacoustic microscopy (PAM) degrades due to the turbidity of the skull that introduces attenuation and distortion of both laser and stimulated ultrasound. In this manuscript, we demonstrated that a newly developed skull optical clearing solution (SOCS) could enhance not only the transmittance of light, but also that of ultrasound in the skull in vitro. Thus the photoacoustic signal was effectively elevated, and the relative strength of the artifacts induced by the skull could be suppressed. Furthermore in vivo studies demonstrated that SOCS could drastically enhance the performance of photoacoustic microscopy for cerebral microvasculature imaging.
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