Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 44, Issue 1, Pages 18-33Publisher
WILEY
DOI: 10.1002/hed.26894
Keywords
biomarkers; ethmoid sinus; intestinal-type sinonasal adenocarcinoma (ITAC); miRNAs; miRNome
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Funding
- Polytechnic University of Marche [PSA-2017- 040020-R.SCIENT.A-2018]
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The study identified that high expression of miR-205 and miR-34c/miR-449 cluster is associated with poor prognosis in patients with ITAC, serving as significant prognostic predictors.
Background Patients with intestinal-type sinonasal adenocarcinoma (ITAC) have an unfavorable prognosis, and new diagnostic and therapeutic approaches are needed to improve clinical management. Methods Next-generation sequencing-based miRNome analysis was performed on 43 ITAC patients who underwent surgical resection, and microRNA (miRNA) data were obtained from 35 cases. Four miRNAs were identified, and their expression levels were detected by reverse-transcription quantitative polymerase chain reaction and related to the relevant patient outcome. Overall survival and disease-free survival rates were evaluated through the Kaplan-Meier method and log-rank test, and multivariate analysis was performed by means of Cox proportional hazard analysis. Results High levels of miR-205 and miR-34c/miR-449 cluster expression were associated with an increased recurrence risk and, therefore, a worse prognosis. Multivariate analysis confirmed that miR-205 and miR-449 were significant prognostic predictors. Conclusions A high expression of miR-205 and miR-449 is independent predictors of poor survival for ITAC patients.
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