4.3 Review

Platelet Dysregulation in the Pathobiology of COVID-19

Related references

Note: Only part of the references are listed.
Article Immunology

Clinical Characteristics of Refractory Coronavirus Disease 2019 in Wuhan, China

Pingzheng Mo et al.

Summary: This study aimed to clarify the characteristics of patients with refractory COVID-19, finding that these patients were older, more likely to be male, and had more underlying comorbid conditions. Patients with refractory disease required more aggressive treatments such as oxygen therapy and mechanical ventilation.

CLINICAL INFECTIOUS DISEASES (2021)

Letter Rheumatology

Reality check on antiphospholipid antibodies in COVID-19-associated coagulopathy

Elena Gkrouzman et al.

ARTHRITIS & RHEUMATOLOGY (2021)

Review Medicine, Research & Experimental

Preventing the development of severe COVID-19 by modifying immunothrombosis

Gerwyn Morris et al.

Summary: This paper discusses the pathophysiology of COVID-19, detailing the processes from initial infection to the development of ARDS. It focuses on the role of inflammatory mediators, thrombus formation, and immunothrombosis, as well as therapeutic combinations for preventing severe COVID-19.

LIFE SCIENCES (2021)

Article Hematology

Antibody-induced procoagulant platelets in severe COVID-19 infection

Karina Althaus et al.

Summary: The pathophysiology of COVID-19-associated thrombosis is multifactorial, involving procoagulant platelets and alterations in various cellular processes. Studies have found that COVID-19 patients exhibit increased platelet dysfunction and apoptosis markers, suggesting a potential role of antibody-mediated procoagulant platelets in contributing to sustained thromboembolic risk in ICU COVID-19 patients.

BLOOD (2021)

Review Cardiac & Cardiovascular Systems

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

Sean X. Gu et al.

Summary: Platelet and endothelial dysfunction are essential components of COVID-19 pathology, while cardiovascular risk factors exacerbate the severity of the disease. Patients with pre-existing cardiovascular disease and risk factors are at the highest risk of death from COVID-19.

NATURE REVIEWS CARDIOLOGY (2021)

Article Hematology

COVID-19 patients often show high-titer non-platelet-activating anti-PF4/heparin IgG antibodies

Justine Brodard et al.

Summary: In COVID-19 patients, a serum-derived factor does not seem to interfere with heparin-induced platelet activation tests, leading to false negative antibody test results. This is crucial for accurate diagnosis of HIT to avoid overdiagnosis and overtreatment.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Hematology

Heparanase expression and activity are increased in platelets during clinical sepsis

Alicia S. Eustes et al.

Summary: During clinical sepsis, translation and enzymatic activity of HPSE are increased in platelets. Increased expression of the active form of HPSE protein is associated with sepsis-associated mortality.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Hematology

Platelet-activating immune complexes identified in critically ill COVID-19 patients suspected of heparin-induced thrombocytopenia

Ishac Nazy et al.

Summary: Our study excludes heparin-induced thrombocytopenia in critically ill COVID-19 patients and identifies platelet-activating immune complexes as a novel mechanism contributing to the disease.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Biochemistry & Molecular Biology

COVID-19 induces a hyperactive phenotype in circulating platelets

Shane P. Comer et al.

Summary: This study found distinct differences in routine full blood count and other clinical laboratory parameters between patients with severe and nonsevere COVID-19. It also determined that all COVID-19 patients possess hyperactive circulating platelets, suggesting abnormal platelet reactivity may contribute to hypercoagulability in COVID-19, influencing the severity of the disease and recovery path complexity.

PLOS BIOLOGY (2021)

Article Medicine, General & Internal

Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

Nina H. Schultz et al.

Summary: This study reports five cases of venous thrombosis and thrombocytopenia occurring 7 to 10 days after receiving the ChAdOx1 nCoV-19 vaccine, suggesting a rare vaccine-induced immune thrombotic thrombocytopenia. The condition, which can lead to catastrophic outcomes such as cerebral venous sinus thrombosis, may be treated with intravenous immune globulin.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Association between thrombocytopenia and 180-day prognosis of COVID-19 patients in intensive care units: A two-center observational study

Yuan Zhu et al.

Summary: Thrombocytopenia in critically ill COVID-19 patients is associated with higher mortality rates and deterioration of organ functions, with platelet count being linked to long-term prognosis.

PLOS ONE (2021)

Letter Immunology

Follow-up of COVID-19 patients: LA is transient but other aPLs are persistent

Olivier Vollmer et al.

AUTOIMMUNITY REVIEWS (2021)

Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Cell & Tissue Engineering

Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein

James Ropa et al.

Summary: This study revealed the effects of SARS-CoV-2 on HSCs/HPCs and immune cells, showing that exposure to the S protein alone can impact these cells negatively, even if they are not infected by the virus. Understanding these effects is crucial for the immune response to SARS-CoV-2 and for hematopoietic cell transplantation.

STEM CELL REVIEWS AND REPORTS (2021)

Review Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Tomasz J. Guzik et al.

CARDIOVASCULAR RESEARCH (2020)

Review Hematology

A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection

Martin J. Page et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2020)

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medical Laboratory Technology

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis

Giuseppe Lippi et al.

CLINICA CHIMICA ACTA (2020)

Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

BLOOD (2020)

Review Medicine, Research & Experimental

Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives

Eugenio Cavalli et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

Article Hematology

Antiphospholipid antibodies in patients with COVID-19: A relevant observation?

Katrien M. J. Devreese et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

Letter Cardiac & Cardiovascular Systems

Heparin-Induced Thrombocytopenia in Severe COVID-19

Florence Daviet et al.

CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid et al.

CIRCULATION RESEARCH (2020)

News Item Multidisciplinary Sciences

Blood vessel injury may spur disease's fatal second phase

Catherine Matacic

SCIENCE (2020)

Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Oncology

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Si Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Hematology

COVID-19 patients exhibit reduced procoagulant platelet responses

Frederik Denorme et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Article Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

Jun Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Critical Care Medicine

The unique characteristics of COVID-19 coagulopathy

Toshiaki Iba et al.

CRITICAL CARE (2020)

Article Multidisciplinary Sciences

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Jose Perdomo et al.

NATURE COMMUNICATIONS (2019)

Article Immunology

Regulatory T Cells Control PF4/Heparin Antibody Production in Mice

Yongwei Zheng et al.

JOURNAL OF IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes

Ivelin I. Ivanov et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Emma Lefrancais et al.

NATURE (2017)

Review Immunology

The immunopathology of sepsis and potential therapeutic targets

Tom van der Poll et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Critical Care Medicine

Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis

Vuong Ba Le et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Article Medicine, General & Internal

Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection

Yaseen M. Arabi et al.

ANNALS OF INTERNAL MEDICINE (2014)

Article Hematology

Risk factors for arterial thrombosis in antiphospholipid syndrome

Aleksandra Matyja-Bednarczyk et al.

THROMBOSIS RESEARCH (2014)

Review Immunology

Platelets and infection - an emerging role of platelets in viral infection

Alice Assinger

FRONTIERS IN IMMUNOLOGY (2014)

Article Infectious Diseases

A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case

Ali S. Omrani et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2013)

Article Medicine, General & Internal

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

Abdullah Assiri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections

Ziad A. Memish et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Immunology

Platelets Present Antigen in the Context of MHC Class I

Lesley M. Chapman et al.

JOURNAL OF IMMUNOLOGY (2012)

Editorial Material Biochemistry & Molecular Biology

Neutrophils release brakes of coagulation

Wolfram Ruf et al.

NATURE MEDICINE (2010)

Article Biochemistry & Molecular Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Steffen Massberg et al.

NATURE MEDICINE (2010)

Article Multidisciplinary Sciences

Extracellular DNA traps promote thrombosis

Tobias A. Fuchs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Hematology

Platelet receptors and signaling in the dynamics of thrombus formation

Jose Rivera et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)

Article Multidisciplinary Sciences

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

Tea Gogishvili et al.

PLOS ONE (2009)

Article Hematology

Abnormality of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura

Bin Liu et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2007)

Review Cell Biology

Hyaluronan fragments: An information-rich system

Robert Stern et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2006)

Article Hematology

Role of mitochondrial permeability transition pore in coated-platelet formation

G Remenyi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

Review Cardiac & Cardiovascular Systems

The adhesion molecule P-selectin and cardiovascular disease

AD Blann et al.

EUROPEAN HEART JOURNAL (2003)

Article Medicine, General & Internal

A cluster of cases of severe acute respiratory syndrome in Hong Kong

KW Tsang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Medicine, General & Internal

Identification of severe acute respiratory syndrome in Canada

SM Poutanen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Medicine, General & Internal

A major outbreak of severe acute respiratory syndrome in Hong Kong

N Lee et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)