4.4 Article

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment

Related references

Note: Only part of the references are listed.
Article Hematology

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma

Michael A. Bauer et al.

Summary: Disruption of normal RNA splicing patterns plays a major role in the pathogenesis of various diseases, particularly cancer. This study investigates the extent and impact of alternative splicing in multiple myeloma, identifying differentially spliced genes and showing potential implications for MM classification and patient risk stratification.

HAEMATOLOGICA (2021)

Article Hematology

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma

Sarah Gooding et al.

Summary: The study found that in patients with myeloma, as the exposure to IMiD drugs increased, the frequency of CRBN abnormalities also increased gradually, with almost one-third of patients having CRBN alterations by the time they were refractory to pomalidomide (POM). These CRBN abnormalities were associated with inferior outcomes to POM in patients already refractory to lenalidomide (LEN).

BLOOD (2021)

Review Genetics & Heredity

Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle

Mayra Petasny et al.

Summary: Pre-mRNA splicing is a crucial process in mammalian gene expression, with alternative splicing contributing significantly to protein diversity. The cell cycle relies on proper pre-mRNA splicing and accurate alternative splicing, which are regulated by various mechanisms. SF3B1, a spliceosome component mutated in multiple cancer types, plays a key role in linking splicing regulation to the cell cycle.

TRENDS IN GENETICS (2021)

Article Hematology

Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

Vikas A. Gupta et al.

Summary: This study found that Venetoclax sensitivity is closely associated with the expression of B-cell genes and genomic features identified in transposase-accessible chromatin sequencing, and there are potential novel biomarkers associated with Venetoclax sensitivity.

BLOOD (2021)

Review Hematology

Splicing factor mutations in hematologic malignancies

Sisi Chen et al.

Summary: Mutations in genes encoding RNA splicing factors are now known to play a key role in various blood disorders, leading to research on biological pathways disrupted by altered splicing and the development of new therapeutic approaches.

BLOOD (2021)

Article Medicine, General & Internal

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

C. D. DiNardo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medical Laboratory Technology

Identification of pathway-based prognostic gene signatures in patients with multiple myeloma

Mohamad Zamani-Ahmadmahmudi et al.

TRANSLATIONAL RESEARCH (2017)

Article Medicine, General & Internal

Multiple myeloma

Shaji K. Kumar et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Biochemistry & Molecular Biology

Therapeutics targeting Bcl-2 in hematological malignancies

Astrid Ruefli-Brasse et al.

BIOCHEMICAL JOURNAL (2017)

Article Multidisciplinary Sciences

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

Therapeutic targeting of splicing in cancer

Stanley Chun-Wei Lee et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Tiffany Y. -T. Hsu et al.

NATURE (2015)

Article Oncology

SF3B1 mutations constitute a novel therapeutic target in breast cancer

Sarah L. Maguire et al.

JOURNAL OF PATHOLOGY (2015)

Review Pharmacology & Pharmacy

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

Thomas R. Webb et al.

DRUG DISCOVERY TODAY (2013)

Article Genetics & Heredity

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

Timothy A. Graubert et al.

NATURE GENETICS (2012)

Article Multidisciplinary Sciences

Frequent pathway mutations of splicing machinery in myelodysplasia

Kenichi Yoshida et al.

NATURE (2011)

Review Medicine, General & Internal

MEDICAL PROGRESS Multiple Myeloma

Antonio Palumbo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Biochemistry & Molecular Biology

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Daisuke Kaida et al.

NATURE CHEMICAL BIOLOGY (2007)

Review Genetics & Heredity

How did alternative splicing evolve?

G Ast

NATURE REVIEWS GENETICS (2004)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.