Tiny contributors to severe obesity inside the gut

Review Endocrinology & Metabolism

Gut microbiota and vitamin status in persons with obesity: A key interplay

Lise Voland et al.

Summary: Vitamins play a crucial role in obesity and related metabolic disorders, with some being synthesized and absorbed by the gut bacteria. Vitamin deficiency can lead to serious health issues, highlighting the importance of monitoring the vitamin status of obese patients and examining alterations in gut microbiota.

OBESITY REVIEWS (2022)

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Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Endocrinology & Metabolism

Gut microbiome, endocrine control of gut barrier function and metabolic diseases

Marion Regnier et al.

Summary: Overweight and obesity are linked to cardiometabolic risk factors, potentially influenced by gut microbiota composition and activity. However, causality between the two is not fully proven. Low-grade inflammation and metabolic disorders are associated with metabolic endotoxaemia and increased gut permeability, but the mechanisms affecting gut barrier regulation and cardiometabolic disorders remain unclear.

JOURNAL OF ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

Global pandemics interconnected - obesity, impaired metabolic health and COVID-19

Norbert Stefan et al.

Summary: Obesity and impaired metabolic health are established risk factors for NCDs such as type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer, and MAFLD, and have been linked to an increased risk of severe COVID-19. Specifically, visceral obesity and characteristics of impaired metabolic health are associated with a high risk of severe COVID-19.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Gastroenterology & Hepatology

Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

Fabian Frost et al.

Summary: The study found that the overall landscape of the microbiome remained stable over time, with factors contributing to metabolic syndrome such as fatty liver disease and diabetes being associated with microbiome instability. On the other hand, stability of the microbiome was determined by factors such as higher initial alpha diversity, female sex, high household income and preserved exocrine pancreatic function.

GUT (2021)

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Article Cell Biology