Relationship of cystatin C, Hs-CRP, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with isolated oligohydramnios

Objectives: We evaluated inflammatory parameters in pregnant women with isolated oligohydramnios. Material and methods: This prospective cross-sectional study enrolled 54 pregnant with isolated oligohydramnios (IO) and 54 matched by gestational week, healthy pregnant with normal amniotic fluid. Maternal plasma levels of cystatin C, hs-CRP, neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), and pregnancy outcomes were compared between two groups. Results: Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than that in the control group (p < 0.05). In the IO group, the rate of primary cesarean section, fetal distress, neonates with meconium-stained, and need for neonatal intensive care unit was higher, and Apgar scores were significantly lower than those in the control group (p < 0.05). There was no significant difference between the groups for meconium-stained neonate rates and the intensive care unit's need in the late-term (410/7-416/7 weeks). Cystatin C, hs-CRP, and PLR were significantly higher in the IO group than the control group (p < 0.05). Cystatin C was positively correlated with the need for neonatal intensive care and negatively correlated with Apgar scores. The PLR was positively correlated with the rate of meconium-stained neonates (p < 0.05). Cystatin C and hs-CRP had significant value in predicting IO (p < 0.05). Conclusions: Maternal serum levels of Cystatin C and hs-CRP may support the diagnosis and prediction of perinatal outcomes as possible biochemical markers in IO cases. In particular, a high level of cystatin C may indicate the need for neonatal intensive care and low Apgar scores. In addition, late-term IO may show similar results in meconium and neonatal intensive care needs compared to without oligohydramnios.

Automated summary

This study evaluated inflammatory parameters in pregnant women with isolated oligohydramnios, and found that serum levels of Cystatin C and hs-CRP may serve as potential biochemical markers for the diagnosis and prediction of perinatal outcomes in these cases.