Journal
GENETICS IN MEDICINE
Volume 24, Issue 5, Pages 986-998Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.gim.2022.01.001
Keywords
22 December 2021; Cancer genetic testing; Oncogenicity; Pathogenicity; Somatic variant; Variant classi fi cation
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Professional societies have published guidelines for the clinical interpretation of somatic variants, but they lack a direct, systematic, and comprehensive set of standards and rules for classification. This leads to inconsistent classification and affects patient care, emphasizing the need for addressing this issue.
Purpose: Several professional societies have published guidelines for the clinical interpretation of somatic variants, which specifically address diagnostic, prognostic, and therapeutic implications. Although these guidelines for the clinical interpretation of variants include data types that may be used to determine the oncogenicity of a variant (eg, population frequency, functional, and in silico data or somatic frequency), they do not provide a direct, systematic, and comprehensive set of standards and rules to classify the oncogenicity of a somatic variant. This insufficient guidance leads to inconsistent classification of rare somatic variants in cancer, generates variability in their clinical interpretation, and, importantly, affects patient care. Therefore, it is essential to address this unmet need. Methods: Clinical Genome Resource (ClinGen) Somatic Cancer Clinical Domain Working Group and ClinGen Germline/Somatic Variant Subcommittee, the Cancer Genomics Consortium, and the Variant Interpretation for Cancer Consortium used a consensus approach to develop a standard operating procedure (SOP) for the classification of oncogenicity of somatic variants. Results: This comprehensive SOP has been developed to improve consistency in somatic variant classification and has been validated on 94 somatic variants in 10 common cancer-related genes. Conclusion: The comprehensive SOP is now available for classification of oncogenicity of somatic variants. ?? 2022 Published by Elsevier Inc. on behalf of American College of Medical Genetics and
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