4.7 Review

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Genome-Wide Estrogen Receptor Activity in Breast Cancer

Anca M. Farcas et al.

Summary: This review explores the relationship between the largest subtype of breast cancer and the estrogen receptor, discussing the dynamic interplay between ER-bound regulatory factors and their impact on estrogen signaling. Research also illustrates how some ER association partners can influence and reprogram the genomic distribution of the estrogen receptor.

ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

CHD2-Related CNS Pathologies

Marc-Michel Wilson et al.

Summary: Epileptic encephalopathies are severe epilepsy syndromes caused by de novo mutations in the chromodomain helicase DNA binding protein 2 (CHD2) gene. Dysregulation of CHD2 leads to early onset epileptic encephalopathy, abnormal brain function, and intellectual disability.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome

Ilana M. Nodelman et al.

Summary: This study reveals that the autoinhibitory elements of the yeast Chd1 remodeler block nucleosome sliding by preventing the initiation of twist defects, controlling the positioning of nucleosomes. The chromodomains and bridge of the remodeler reinforce each other to block sliding when the DNA-binding domain is not bound to DNA, targeting nucleotide-free and ADP-bound states of the ATPase motor. This uncouples the ATP binding/hydrolysis cycle from DNA translocation around the histone core, suggesting a mechanism for regulating chromatin remodeling.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemistry & Molecular Biology

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

Ville Paakinaho et al.

Summary: SUMOylation regulates the specificity of GR by modulating its chromatin protein network and accessibility at GR-bound enhancers, affecting chromatin binding and target gene expression.

NUCLEIC ACIDS RESEARCH (2021)

Article Cell Biology

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors

Hanseul Kweon et al.

Summary: Deletion of the CHD8 gene in mice leads to near-complete elimination of neocortical structures, yet the mice display mostly normal behaviors, including hyperactivity and increased social interaction. These changes are accompanied by thalamic hyperactivity and enhanced somatosensory function, suggesting a critical role of excitatory neuronal CHD8 in neurodevelopment and a compensatory response in CHD8 haploinsufficiency-related macrocephaly.

CELL REPORTS (2021)

Article Cell Biology

The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Akihiro Nita et al.

Summary: CHD8 is an ATP-dependent chromatin-remodeling factor encoded by the most frequently mutated gene in individuals with autism spectrum disorder. It is highly expressed in hematopoietic stem cells and plays a key role in maintaining their stemness, with deficiency leading to cell cycle arrest and differentiation block. Additional ablation of p53 rescues the impaired stem cell function and differentiation block caused by CHD8 deficiency.

CELL REPORTS (2021)

Article Biology

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan et al.

Summary: The study identified the TWIST1-CRM module as crucial for NCC development, with its activity level influencing cell differentiation and migration potential. Loss of the module function results in abnormal cell fate choices.

ELIFE (2021)

Article Genetics & Heredity

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Shaun Hurley et al.

Summary: This study created new Chd8 mouse models with varying levels of deficiency to investigate the functions of CHD8 during embryonic cortical development. The findings suggest that CHD8 plays important and dosage-sensitive roles in controlling the proliferation of intermediate progenitors, neurodevelopmental gene expression, and neural progenitor fate in the embryonic neocortex.

MOLECULAR AUTISM (2021)

Article Hematology

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability

Zhaowei Tu et al.

Summary: The Chd8 gene encodes a chromatin remodeler essential for normal hematopoiesis, with its deficiency leading to severe anemia and instability of HSPCs. CHD8 maintains hematopoiesis by regulating ATM-P53-mediated survival of HSPCs.

BLOOD (2021)

Article Genetics & Heredity

Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy

Ilaria Parenti et al.

Summary: The CHD5 gene, located in the critical 1p36 microdeletion region, encodes a subunit of the NuRD complex required for neuronal development. Variants in this gene were identified in 16 unrelated individuals, showing features like intellectual disability, speech delay, and epilepsy.

HUMAN GENETICS (2021)

Article Multidisciplinary Sciences

Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation

Sara Badodi et al.

Summary: The deregulation of chromatin modifiers is found to be essential in the pathogenesis of medulloblastoma. In certain cases, there is a BMI1-dependent sensitivity to deregulation of inositol metabolism. Additionally, the study demonstrates that the combination of IP6 with cisplatin enhances cytotoxicity in medulloblastoma.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

The autism-associated protein CHD8 is required for cerebellar development and motor function

Atsuki Kawamura et al.

Summary: Mutations in the gene encoding CHD8 have been found to be a highly penetrant risk factor for ASD. Dysfunction of CHD8 in the cerebellum impairs proliferation and differentiation of cerebellar granule neuron progenitors, leading to cerebellar hypoplasia and motor coordination defects, but not ASD-like behavioral abnormalities.

CELL REPORTS (2021)

Review Biochemistry & Molecular Biology

A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling

Lijuan Yan et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

A regulatory role for CHD2 in myelopoiesis

Farzaneh Shahin Varnoosfaderani et al.

EPIGENETICS (2020)

Article Biochemistry & Molecular Biology

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

Theodore G. Drivas et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2020)

Article Multidisciplinary Sciences

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

Yichen Zhong et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

A genomic and epigenomic atlas of prostate cancer in Asian populations

Jing Li et al.

NATURE (2020)

Article Cell Biology

CHD9 upregulates RUNX2 and has a potential role in skeletal evolution

Axel H. Newton et al.

BMC MOLECULAR AND CELL BIOLOGY (2020)

Article Immunology

Chd4 choreographs self-antigen expression for central immune tolerance

Yoshihiko Tomofuji et al.

NATURE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

Jingmei Hsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Cell & Tissue Engineering

CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling

Caojie Liu et al.

STEM CELLS INTERNATIONAL (2020)

Article Multidisciplinary Sciences

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities

Shun Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Magdalena B. Rother et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

The human chd8 gene is transcribed from two distant upstream promoters

Gary R. Kunkel et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Peiman Shooshtarizadeh et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis

Tessa Arends et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling

Anton Sabantsev et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

Felicity Newel et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans

Alexandra Boginya et al.

SCIENTIFIC REPORTS (2019)

Editorial Material Biochemistry & Molecular Biology

Uncovering a New Step in Sliding Nucleosomes

Gregory D. Bowman

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Organization of Chromatin by Intrinsic and Regulated Phase Separation

Bryan A. Gibson et al.

Article Multidisciplinary Sciences

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Aviv Rom et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Shaun Moore et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency

A. Ayanna Wade et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Yuan Cheng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

Article Multidisciplinary Sciences

CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma

Lisa D. McKenzie et al.

SCIENTIFIC REPORTS (2019)

Article Genetics & Heredity

Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability

Genay O. Pilarowski et al.

JOURNAL OF MEDICAL GENETICS (2018)

Article Biochemistry & Molecular Biology

Chd9 mediates highly loosened chromatin structure in growing mouse oocytes

Masatoshi Ooga et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Urology & Nephrology

Clinical implications of PTEN loss in prostate cancer

Tamara Jamaspishvili et al.

NATURE REVIEWS UROLOGY (2018)

Article Biochemistry & Molecular Biology

The ATPase motor of the Chd1 chromatin remodeler stimulates DNA unwrapping from the nucleosome

Joshua M. Tokuda et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers

A. A. Serandour et al.

ONCOGENE (2018)

Article Multidisciplinary Sciences

Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome

Catherine Belanger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

CHD4 and the NuRD complex directly control cardiac sarcomere formation

Caralynn M. Wilczewski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Neurosciences

ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis

Godwin Sokpor et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Alex H. Wagner et al.

NATURE COMMUNICATIONS (2018)

Review Multidisciplinary Sciences

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Tejas Yadav et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities

Benjamin J. Manning et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome

Ilana M. Nodelman et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure

Xiaoyu Liu et al.

NATURE (2017)

Article Multidisciplinary Sciences

Prevalence and architecture of de novo mutations in developmental disorders

Jeremy F. McRae et al.

NATURE (2017)

Article Multidisciplinary Sciences

Nucleosome-Chd1 structure and implications for chromatin remodelling

Lucas Farnung et al.

NATURE (2017)

Article Neurosciences

Germline Chd8 haploinsufficiency alters brain development in mouse

Andrea L. Gompers et al.

NATURE NEUROSCIENCE (2017)

Review Cell Biology

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

Cedric R. Clapier et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Cell Biology

Understanding nucleosome dynamics and their links to gene expression and DNA replication

William K. M. Lai et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Simon J. Baumgart et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Yuichiro Semba et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

Helen Hoffmeister et al.

NUCLEIC ACIDS RESEARCH (2017)

Review Biology

DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance

Magdalena B. Rother et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

Article Multidisciplinary Sciences

Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development

Kesavan Meganathan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Multidisciplinary Sciences

Epigenetic plasticity and the hallmarks of cancer

William A. Flavahan et al.

SCIENCE (2017)

Article Cell Biology

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma

Sara Badodi et al.

CELL REPORTS (2017)

Article Cell Biology

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Randall J. Platt et al.

CELL REPORTS (2017)

Article Cell Biology

Covalent Modifications of Histone H3K9 Promote Binding of CHD3

Adam H. Tencer et al.

CELL REPORTS (2017)

Article Medicine, Research & Experimental

The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer

Alea A. Mills

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Review Biochemistry & Molecular Biology

A Phase Separation Model for Transcriptional Control

Denes Hnisz et al.

Review Cell Biology

Hypertranscription in Development, Stem Cells, and Regeneration

Michelle Percharde et al.

DEVELOPMENTAL CELL (2017)

Article Biochemistry & Molecular Biology

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

Vijayalakshmi Kari et al.

EMBO REPORTS (2016)

Article Biochemistry & Molecular Biology

The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain

Biswaranjan Mohanty et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

Martijn S. Luijsterburg et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells

Maud de Dieuleveult et al.

NATURE (2016)

Article Multidisciplinary Sciences

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Yuta Katayama et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

Eric Metzger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome

Ilana M. Nodelman et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

Eric Metzger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Oncology

RNAi screens identify CHD4 as an essential gene in breast cancer growth

Carolina D'Alesio et al.

ONCOTARGET (2016)

Article Biotechnology & Applied Microbiology

Widespread RNA binding by chromatin-associated proteins

David G. Hendrickson et al.

GENOME BIOLOGY (2016)

Article Oncology

Coordinate Loss of MAP3K7 and CHD1 Promotes Aggressive Prostate Cancer

Lindsey Ulkus Rodrigues et al.

CANCER RESEARCH (2015)

Article Developmental Biology

Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification

Aoife O'Shaughnessy-Kirwan et al.

DEVELOPMENT (2015)

Article Developmental Biology

CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis

Shinnosuke Suzuki et al.

DEVELOPMENT (2015)

Review Biochemistry & Molecular Biology

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

Arigela Harikumar et al.

EMBO REPORTS (2015)

Article Biochemistry & Molecular Biology

CHD6 regulates the topological arrangement of the CFTR locus

Ana Sancho et al.

HUMAN MOLECULAR GENETICS (2015)

Article Biochemical Research Methods

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

Dharmendra Dingar et al.

JOURNAL OF PROTEOMICS (2015)

Article Biochemistry & Molecular Biology

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

Chen Shen et al.

MOLECULAR CELL (2015)

Article Genetics & Heredity

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

Mark M. Pomerantz et al.

NATURE GENETICS (2015)

Article Oncology

ESR1 mutations-a mechanism for acquired endocrine resistance in breast cancer

Rinath Jeselsohn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Review Neurosciences

From the genetic architecture to synaptic plasticity in autism spectrum disorder

Thomas Bourgeron

NATURE REVIEWS NEUROSCIENCE (2015)

Article Clinical Neurology

CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures

Rhys H. Thomas et al.

NEUROLOGY (2015)

Article Multidisciplinary Sciences

Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription

Fong Ming Koh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9

Bing Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell & Tissue Engineering

CHD2 is Required for Embryonic Neurogenesis in the Developing Cerebral Cortex

Tianjin Shen et al.

STEM CELLS (2015)

Review Cell & Tissue Engineering

Chromodomain Helicase DNA-Binding Proteins in Stem Cells and Human Developmental Diseases

Joseph A. Micucci et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Multidisciplinary Sciences

Embryonic stem cell differentiation requires full length Chd1

Paolo Piatti et al.

SCIENTIFIC REPORTS (2015)

Review Genetics & Heredity

Chromatin Remodelers: From Function to Dysfunction

Gernot Laengst et al.

GENES (2015)

Article Biochemistry & Molecular Biology

The function of chromatin modifiers in lineage commitment and cell fate specification

Jason Signolet et al.

FEBS JOURNAL (2015)

Article Biochemistry & Molecular Biology

Human CHD2 Is a Chromatin Assembly ATPase Regulated by Its Chromo- and DNA-binding Domains

Jessica C. Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Oncology

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Philip A. Watson et al.

NATURE REVIEWS CANCER (2015)

Review Oncology

Role of CHD5 in Human Cancers: 10 Years Later

Venkatadri Kolla et al.

CANCER RESEARCH (2014)

Article Biochemistry & Molecular Biology

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

Raphael Bernier et al.

Article Cell & Tissue Engineering

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner

Rodrigo L. dos Santos et al.

CELL STEM CELL (2014)

Article Behavioral Sciences

CHD2 mutations in Lennox-Gastaut syndrome

Caroline Lund et al.

EPILEPSY & BEHAVIOR (2014)

Article Biochemistry & Molecular Biology

CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice

Yuelong Liu et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

The Tumor Suppressor Chromodomain Helicase DNA-binding Protein 5 (CHD5) Remodels Nucleosomes by Unwrapping

Jinhua Quan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Inappropriate p53 activation during development induces features of CHARGE syndrome

Jeanine L. Van Nostrand et al.

NATURE (2014)

Article Multidisciplinary Sciences

The contribution of de novo coding mutations to autism spectrum disorder

Ivan Iossifov et al.

NATURE (2014)

Review Genetics & Heredity

Dynamic regulation of transcriptional states by chromatin and transcription factors

Ty C. Voss et al.

NATURE REVIEWS GENETICS (2014)

Article Biochemistry & Molecular Biology

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

Alicia Subtil-Rodriguez et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

Aarathi Sugathan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Neurosciences

A de novo convergence of autism genetics and molecular neuroscience

Niklas Krumm et al.

TRENDS IN NEUROSCIENCES (2014)

Article Multidisciplinary Sciences

Chd5 orchestrates chromatin remodelling during sperm development

Wangzhi Li et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Recurrent de novo mutations implicate novel genes underlying simplex autism risk

B. J. O'Roak et al.

NATURE COMMUNICATIONS (2014)

Article Clinical Neurology

CHD2 haploinsufficiency is associated with developmental delay, intellectual disability, epilepsy and neurobehavioural problems

Sebastien Chenier et al.

JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2014)

Review Biochemistry & Molecular Biology

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

Geeta J. Narlikar et al.

Article Biochemistry & Molecular Biology

Punctuated Evolution of Prostate Cancer Genomes

Sylvan C. Baca et al.

Article Biochemistry & Molecular Biology

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

Anke Sparmann et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal

Alessia Gagliardi et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Nucleosome sliding by Chd1 does not require rigid coupling between DNA-binding and ATPase domains

Ilana M. Nodelman et al.

EMBO REPORTS (2013)

Review Cell Biology

A double take on bivalent promoters

Philipp Voigt et al.

GENES & DEVELOPMENT (2013)

Review Biotechnology & Applied Microbiology

CHD chromatin remodelling enzymes and the DNA damage response

Fintan K. T. Stanley et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2013)

Article Multidisciplinary Sciences

Deterministic direct reprogramming of somatic cells to pluripotency

Yoach Rais et al.

NATURE (2013)

Review Genetics & Heredity

From neural development to cognition: unexpected roles for chromatin

Jehnna L. Ronan et al.

NATURE REVIEWS GENETICS (2013)

Review Biochemistry & Molecular Biology

Nucleosome sliding mechanisms: new twists in a looped history

Felix Mueller-Planitz et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Cell & Tissue Engineering

NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells

Min Luo et al.

STEM CELLS (2013)

Article Cell Biology

Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression

Shilpi Paul et al.

CELL REPORTS (2013)

Review Cell & Tissue Engineering

NuRD and Pluripotency: A Complex Balancing Act

Guang Hu et al.

CELL STEM CELL (2012)

Article Biochemistry & Molecular Biology

Chd2 interacts with H3.3 to determine myogenic cell fate

Akihito Harada et al.

EMBO JOURNAL (2012)

Article Environmental Sciences

Chromodomain helicase DNA-binding protein 2 affects the repair of X-ray and UV-Induced DNA damage

Sangeetha Rajagopalan et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2012)

Article Genetics & Heredity

Deletion of the RMGA and CHD2 genes in a child with epilepsy and mental deficiency

Leonardo P. Capelli et al.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2012)

Article Biochemistry & Molecular Biology

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

Aleksandra A. Watson et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Histone H1 Recruitment by CHD8 Is Essential for Suppression of the Wnt-beta-Catenin Signaling Pathway

Masaaki Nishiyama et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

MBD2 and Multiple Domains of CHD4 Are Required for Transcriptional Repression by Mi-2/NuRD Complexes

Julita Ramirez et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

Suppression of the antiviral response by an influenza histone mimic

Ivan Marazzi et al.

NATURE (2012)

Article Multidisciplinary Sciences

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Warren A. Whyte et al.

NATURE (2012)

Article Multidisciplinary Sciences

The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso et al.

NATURE (2012)

Article Multidisciplinary Sciences

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

Stephan J. Sanders et al.

NATURE (2012)

Article Multidisciplinary Sciences

Topological domains in mammalian genomes identified by analysis of chromatin interactions

Jesse R. Dixon et al.

NATURE (2012)

Article Multidisciplinary Sciences

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

Brian J. O'Roak et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness

S. Huang et al.

ONCOGENE (2012)

Article Multidisciplinary Sciences

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Wenbing Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

Catherine A. Musselman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders

Karim Bouazoune et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

Jessica D. Kessler et al.

SCIENCE (2012)

Article Hematology

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

Katherine E. Berquam-Vrieze et al.

BLOOD (2011)

Article Biochemistry & Molecular Biology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens et al.

Review Biochemistry & Molecular Biology

Chromatin Connections to Pluripotency and Cellular Reprogramming

Stuart H. Orkin et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Biochemistry & Molecular Biology

Snf2-family proteins: chromatin remodellers for any occasion

Daniel P. Ryan et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Structural insights into regulation and action of SWI2/SNF2 ATPases

Glenn Hauk et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

Daniel P. Ryan et al.

EMBO JOURNAL (2011)

Article Cell Biology

Mediator coordinates PIC assembly with recruitment of CHD1

Justin J. Lin et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

Robyn E. Mansfield et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Extranucleosomal DNA Binding Directs Nucleosome Sliding by Chd1

Jeffrey N. McKnight et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

The genomic complexity of primary human prostate cancer

Michael F. Berger et al.

NATURE (2011)

Article Genetics & Heredity

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

Erik Engelen et al.

NATURE GENETICS (2011)

Article Biochemistry & Molecular Biology

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

Aaron A. Goodarzi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Review Oncology

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

Anne Y. Lai et al.

NATURE REVIEWS CANCER (2011)

Article Cell & Tissue Engineering

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease

Mercedes Pardo et al.

CELL STEM CELL (2010)

Review Developmental Biology

Nucleosome positioning: How is it established, and why does it matter?

Marta Radman-Livaja et al.

DEVELOPMENTAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8

Joel A. Yates et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome

Tserendulam Batsukh et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis

Gabriel E. Zentner et al.

HUMAN MOLECULAR GENETICS (2010)

Article Biochemistry & Molecular Biology

The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor

Glenn Hauk et al.

MOLECULAR CELL (2010)

Article Endocrinology & Metabolism

Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8

Tushar Menon et al.

MOLECULAR ENDOCRINOLOGY (2010)

Article Biochemistry & Molecular Biology

Deletion of the Chd6 exon 12 affects motor coordination

Melissa J. Lathrop et al.

MAMMALIAN GENOME (2010)

Article Multidisciplinary Sciences

CHD7 cooperates with PBAF to control multipotent neural crest formation

Ruchi Bajpai et al.

NATURE (2010)

Article Multidisciplinary Sciences

Functional impact of global rare copy number variation in autism spectrum disorders

Dalila Pinto et al.

NATURE (2010)

Article Genetics & Heredity

CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell- Specific Gene Expression

Michael P. Schnetz et al.

PLOS GENETICS (2010)

Review Biochemistry & Molecular Biology

The Biology of Chromatin Remodeling Complexes

Cedric R. Clapier et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Rheumatology

Expression of the Dermatomyositis Autoantigen Mi-2 in Regenerating Muscle

Andrew L. Mammen et al.

ARTHRITIS AND RHEUMATISM (2009)

Article Cell Biology

Transcriptional competence in pluripotency

Edupuganti V. S. Raghu Ram et al.

GENES & DEVELOPMENT (2009)

Article Biochemistry & Molecular Biology

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns

Michael P. Schnetz et al.

GENOME RESEARCH (2009)

Article Biochemistry & Molecular Biology

Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc

C. Elizabeth Caldon et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

Alexandre Gaspar-Maia et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Chromatin organization marks exon-intron structure

Schraga Schwartz et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene

M. Rodriguez-Paredes et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5

Hua Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

Lena Ho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary et al.

SCIENCE (2009)

Article Genetics & Heredity

Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis

Shashikant Kulkarni et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2008)

News Item Cell & Tissue Engineering

Global transcription in pluripotent embryonic stem cells

Sol Efroni et al.

CELL STEM CELL (2008)

Article Physiology

A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype

Concetta G. A. Marfella et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2008)

Article Biochemistry & Molecular Biology

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks

Lluis Morey et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

BAT3 and SET1A Form a Complex with CTCFL/BORIS To Modulate H3K4 Histone Dimethylation and Gene Expression

Phuongmai Nguyen et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Solution structure of the BRK domains from CHD7

Mark D. Allen et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

CHD1 motor protein is required for deposition of histone variant h3.3 into chromatin in vivo

Alexander Y. Konev et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Molecular implications of evolutionary differences in CHD double chromodomains

John F. Flanagan et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Review Biology

A new paradigm for developmental biology

John S. Mattick

JOURNAL OF EXPERIMENTAL BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

The Chd family of chromatin remodelers

Concetta G. A. Marfella et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)

Review Biochemistry & Molecular Biology

The role of chromatin during transcription

Bing Li et al.

Article Biochemistry & Molecular Biology

CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis

Thomas Lutz et al.

FEBS LETTERS (2006)

Article Cell Biology

Mutation of the SNF2 family member Chd2 affects mouse development and survival

Concetta G. A. Marfella et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

CTCF-dependent chromatin insulator is linked to epigenetic remodeling

Ko Ishihara et al.

MOLECULAR CELL (2006)

Article Multidisciplinary Sciences

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

Yan Shou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes

Chris Stockdale et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Rajini Srinivasan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex

S Surapureddi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Cell Biology

In vivo association of CReMM/CHD9 with promoters in osteogenic cells

I Shur et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

BE Bernstein et al.

Article Multidisciplinary Sciences

CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1

JQ Ling et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Suppression of STAT3 activity by duplin, which is a negative regulator of the Wnt signal

K Yamashina et al.

JOURNAL OF BIOCHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

Andrew Flaus et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

The human SWI/SNF subunit Brm is a regulator of alternative splicing

E Batsche et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains

RJ Sims et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Double chromodomains cooperate to recognize the methylated histone H3 tail

JF Flanagan et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein

I Shur et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly

A Lusser et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Review Cell Biology

The SANT domain: a unique histone-tail-binding module?

LA Boyer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

N Fujita et al.

Article Biochemistry & Molecular Biology

Early embryonic death in mice lacking the β-catenin-binding protein duplin

M Nishiyama et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

MTA3, a Mi-2/NuRD complex subunit, an invasive growth pathway in breast

N Fujita et al.

Article Multidisciplinary Sciences

SATB1 targets chromatin remodelling to regulate genes over long distances

D Yasui et al.

NATURE (2002)

Article Biochemistry & Molecular Biology

RNA polymerase II elongation factors of Saccharomyces cerevisiae:: a targeted proteomnics approach

NJ Krogan et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Multidisciplinary Sciences

Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator

S Surapureddi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases

EF Schuster et al.

MAMMALIAN GENOME (2002)

Article Biochemistry & Molecular Biology

Mi2, an auto-antigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor

HB Wang et al.

NUCLEIC ACIDS RESEARCH (2001)

Article Multidisciplinary Sciences

Deacetylation of p53 modulates its effect on cell growth and apoptosis

JY Luo et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

A novel β-catenin-binding protein inhibits β-catenin-dependent Tcf activation and axis formation

I Sakamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

Chromodomains are protein-RNA interaction modules

A Akhtar et al.

NATURE (2000)