Journal
GENE
Volume 809, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.gene.2021.146006
Keywords
Deletion; insertion polymorphism; Genetic polymorphism; Forensic application; Genetic relationship; Chinese Hunan Han
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The study analyzed the genetic polymorphisms of 57 autosomal DIPs and forensic application evaluations in the Chinese Hunan Han population, showing that the combination of these markers could be used for forensic individual identification and paternity testing, as well as effectively distinguishing among different continental populations.
Deletion/insertion polymorphism (DIP) is a promising genetic marker of DNA length polymorphism. However, there are relatively few studies on the exploration of DIP genetic polymorphisms and investigation of population genetic data at present, which limits its application in forensic identification. In this study, the genetic polymorphisms of 57 autosomal DIPs and forensic application evaluations of the novel panel were analyzed in Chinese Hunan Han population using capillary electrophoresis platform, and the differences of genetic polymorphic distributions at these loci were compared among the Hunan Han and 26 reference populations. The present results showed the combination of total 57 DIPs could be a robust tool for forensic individual identification and paternity testing. Due to the different allele frequency distributions in the different continental populations, the system could also effectively distinguish among East Asian, European and African populations.
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