4.6 Article

Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Multidisciplinary Sciences

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang et al.

Summary: Cystine uptake promotes GPX4 synthesis by activating mTORC1, sensitizing cancer cells to ferroptosis. Inhibiting mTORC1 decreases GPX4 protein levels and enhances the effectiveness of ferroptosis inducers in cancer treatment.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Enyong Dai et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

Choosing the right cell line for renal cell cancer research

Klaudia K. Brodaczewska et al.

MOLECULAR CANCER (2016)

Review Urology & Nephrology

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

Daniel Fantus et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Oncology

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

Min-Young Kwon et al.

ONCOTARGET (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Medicine, Research & Experimental

Lipid Peroxidation and Antioxidant System in Erythrocytes of Patients with Renal Cell Carcinoma

M. N. Gerasimenko et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Urology & Nephrology

Histological Subtype is an Independent Predictor of Outcome for Patients With Renal Cell Carcinoma

Bradley C. Leibovich et al.

JOURNAL OF UROLOGY (2010)