Failure to Achieve Target Drug Concentrations During Induction and Not HLA-DQA1*05 Carriage Is Associated With Antidrug Antibody Formation in Patients With Inflammatory Bowel Disease

Article Gastroenterology & Hepatology

Effect of IBD medications on COVID-19 outcomes: results from an international registry

Ryan C. Ungaro et al.

Summary: Combination therapy and thiopurines may be associated with an increased risk of severe COVID-19, while no significant differences were observed when comparing classes of biologicals. These findings warrant confirmation in large population-based cohorts.

GUT (2021)

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Article Pharmacology & Pharmacy

Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease

Ye Xiong et al.

Summary: The study identified blood biomarkers for rapid clearance and exposure targets of infliximab in pediatric Crohn's disease. Higher AUC during induction was associated with better treatment outcomes and lower surgery rates for patients.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Gastroenterology & Hepatology

Ulcerative Colitis Narrative Global Survey Findings:The Impact of Living With Ulcerative Colitis-Patients' and Physicians' View

Marla C. Dubinsky et al.

Summary: The global patient and physician survey on Ulcerative Colitis (UC) revealed that patients experience diagnostic delay, poor disease control, and adverse impact on their quality of life. The majority of patients felt that UC controlled their life rather than them controlling their disease. Emotional and mental health issues were infrequently discussed at routine appointments by physicians, contrasting with patients' perspectives.

INFLAMMATORY BOWEL DISEASES (2021)

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Article Gastroenterology & Hepatology