Influence of clear cell carcinoma on the post-hepatectomy prognosis of patients with hepatocellular carcinoma

Aim: The authors aimed to identify factors that independently influence the survival of patients with primary clear cell carcinoma of the liver (PCCCL). Methods: A total of 470 patients with hepatocellular carcinoma were retrospectively analyzed. Multivariate Cox analysis was used to identify potential factors associated with prognosis of PCCCL. Results: Patients with PCCCL showed significantly higher disease-free survival (DFS) and overall survival (OS) compared with patients with non-clear cell hepatocellular carcinoma. Multivariate analysis revealed that AFP level, tumor size, liver cirrhosis and portal vein tumor thrombosis were risk factors for DFS. Tumor size, capsule formation and Ki-67 were risk factors for OS. Satellite nodules acted as a protective factor for DFS and OS. Conclusion: PCCCL is associated with better prognosis in hepatocellular carcinoma. Tumor size and satellite nodules may be independent predictors of OS and DFS.

Automated summary

Patients with primary clear cell carcinoma of the liver (PCCCL) have better survival rates compared to patients with other types of hepatocellular carcinoma. Factors such as AFP level, tumor size, liver cirrhosis, and portal vein tumor thrombosis are risk factors for disease-free survival (DFS), while tumor size, capsule formation, and Ki-67 are risk factors for overall survival (OS). Satellite nodules are protective factors for both DFS and OS.