Journal
FUTURE ONCOLOGY
Volume 18, Issue 6, Pages 661-667Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2021-0683
Keywords
androgen deprivation therapy; cytokines; inflammation; prostate cancer
Categories
Funding
- African Development Bank under Uganda Cancer Institute [P-Z1-IB0-024]
- NIH Office of the Director
- National Institute of Dental and Craniofacial Research
- National Institute of Neurological Disorders and Stroke
- National Heart, Lung, and Blood Institute
- Fogarty International Center
- National Institute on Minority Health and Health Disparities [D43TW010132]
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
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The study found that plasma levels of proinflammatory cytokines IL-6 and IL-8 were elevated in prostate cancer patients, potentially related to disease progression and levels of prostate-specific antigen.
Background: The possible clinical application of specific cytokines and chemokines contributing to tumorigenesis and the clinical outcome of several cancers has been reported. However, less invasive and easily applicable biomarkers in Prostate cancer diagnosis and prognostication are still lacking. This study assessed the levels of plasma cytokines in prostate cancer patients as potential biomarkers for noninvasive early diagnosis. Methods: The plasma levels of nine cytokines, IL-6, IL-8, IL-10, IL-1 beta, IL-17A, IL-2, M-CSF, IL-12 and IFN-alpha, were detected by Luminex liquid array-based multiplexed immunoassays in 56 prostate cancer patients on androgen deprivation therapy and radiotherapy and 27 normal healthy controls. Results: Levels of plasma proinflammatory cytokines IL-6 and IL-8 were markedly increased in prostate cancer patients compared with controls. There was, however, no significant difference in the concentrations of all cytokines in prostate cancer patients compared with controls. Increasing levels of IL-6 and IL-8 were significantly associated with high levels of plasma prostate-specific antigen (p < 0.05). Conclusion: Proinflammatory cytokines IL-6 and IL-8 are potential biomarkers for prostate cancer pathogenesis and could serve as markers of disease progression.
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