Journal
FUTURE MICROBIOLOGY
Volume 16, Issue 15, Pages 1153-1160Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0056
Keywords
alginate nanoparticles; Aspergillus flavus; Aspergillus fumigatus; Galleria mellonella; synergism
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/07993-0, 2017/19374-9, 2018/13877-1]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [405556/2018-7]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [303373/2019-9]
- FAPESP [2018/03708-8]
- CNPq [303373/2019-9]
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The study demonstrated that the combination of miltefosine (MFS) and loaded-alginate nanoparticles (MFS-AN) with voriconazole (VRC) may enhance the antifungal therapy against Aspergillus fumigatus and Aspergillus flavus.
Aim: To evaluate the activity of miltefosine (MFS), in its free form or loaded-alginate nanoparticles (MFS-AN), alone or combined with voriconazole (VRC) on Aspergillus fumigatus and Aspergillus flavus. Materials & methods: Broth microdilution assay was used for susceptibility testing of Aspergillus isolates, and the antifungal efficacy was assessed using the aspergillosis model in Galleria mellonella larvae. Results: The in vitro synergistic effect of MFS with VRC was observed only against A. fumigatus, whereas both combined therapies (MFS + VRC and MFS-AN + VRC) showed synergism in reducing the larval mortality rate and fungal burden in the larvae infected by A. fumigatus and A. flavus. Conclusions: MFS and MFS-AN combined with VRC may be an important strategy for improving antifungal therapy against aspergillosis.
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