Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 180, Issue -, Pages 85-94Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2022.01.007
Keywords
Vitamin C; Dehydroascorbate; NF-kappa B; Inflammation; Reactive oxygen species
Funding
- National Natural Science Foundation of China [22177045, 21672091]
Ask authors/readers for more resources
The study found that vitamin C can form an efficient redox cycle with intracellular glutathione and copper ions, generating reactive oxygen species (ROS), which in turn inhibits NF-kappa B-mediated inflammation.
Vitamin C (VC), widely found in vegetables and fruits, operates as an electron donor to perform various biological functions including anti-inflammatory activity. However, the mechanisms by which VC inhibits inflammation remain insufficiently understood. Accordingly, we performed a detail mechanistic study on antiinflammatory activity of VC at millimolar (pharmacological) concentrations in lipopolysaccharides-stimulated RAW264.7 cells. It was found that VC and its two-electron oxidative product, dehydroascorbate (DHA) constructs an efficient redox cycle with the aid of intracellular glutathione and copper ions, thereby facilitating the generation of reactive oxygen species (ROS) and the ROS-dependent inhibition against the NF-kappa B-mediated inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available