Journal
FOOD CHEMISTRY
Volume 369, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.130928
Keywords
Nontargeted screening; Fragmentation characteristics; Veterinary drugs; Veterinary drugs Drug metabolites; Suspect; Suspect screening Liquid chromatography-high-resolution mass; spectrometry
Funding
- National Key Research and Devel-opment Program of China [2018YFC1602400, 2019YFC1605100]
- National Natural Science Foundation - China [21974140, 22174141]
- nnovation Program (DICP) - Science and Research from Dalian Institute of Chemical Physics, Chinese Academy of Sciences [I202108]
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A novel nontargeted screening strategy for veterinary drugs and their metabolites based on fragmentation characteristics was developed and applied successfully to egg samples, demonstrating its potential for comprehensive safety evaluation of animal-derived foods.
Nontargeted screening of both veterinary drugs and their metabolites is important for comprehensive safety evaluation of animal-derived foods. In this study, a novel nontargeted screening strategy was developed for veterinary drugs and their metabolites based on fragmentation characteristics from ultrahigh-performance liquid chromatography-high-resolution mass spectrometry. First, an in-house database of mass spectra including 3,710 veterinary drugs and their metabolites was constructed. Second, fragmentation characteristics of parent drugs and their metabolites in mass spectrometry were investigated and summarized. Then, a nontargeted screening procedure was established based on fragmentation characteristics to screen unknown parent drugs and their metabolites. Finally, the strategy was applied to 33 egg samples, and four veterinary drugs and three drug metabolites were determined and identified. These results showed that the developed strategy can realize suspect and nontargeted screening of veterinary drugs and their metabolites, and can also be applied to other animalderived foods.
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