Journal
FOOD CHEMISTRY
Volume 366, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.130575
Keywords
Metallo-covalent organic frameworks (MCOFs); Metallophthalocyanine; Impedimetric aptasensor; Tobramycin detection; Sensitive antibiotic analysis
Funding
- Major Special Project on Public Welfare of Henan Province [201300110100]
- Distinguished Youth Science Foundation of Henan Province [202300410492]
- Key Research Project of University of Henan Province [19zx004]
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Two bimetallic CoNi-based metallo-covalent organic frameworks were utilized as sensitive platforms for impedimetric aptasensors to efficiently detect tobramycin. One of the MCOFs showed a low detection limit and superior sensing performance, with good applicability for detecting tobramycin in milk or chicken eggs.
Two bimetallic CoNi-based metallo-covalent organic frameworks (MCOFs) were prepared and explored as the sensitive platforms of impedimetric aptasensors for efficient detection of tobramycin (TOB). The two CoNi-MCOFs were constructed using metallophthalocyanine tetra-amine (MPc-TA, M = Co2+ or Ni2+) and 4,4'-(1,10-phen-anthroline-2,9-diyl) dibenzaldehyde (PTD) as building units and further coordinating to the secondary metal ions (Ni2+ or Co2+) by phenanthroline. Interestingly, the immobilization ability of CoPc-TA-PTD (Ni) to TOB-targeted aptamer is higher than that of NiPc-TA-PTD(Co) due to its stronger binding interactions to aptamer. As a result, the CoPc-TA-PTD(Ni)-based aptasensor shows the superior TOB detection ability, giving a low detection limit of 0.07 fg mL(-1) and satisfied sensing performances, such as high selectivity, good reproducibility, and excellent stability. Also, the aptasensor shows the acceptable applicability for detecting TOB in milk or chicken egg. This MCOFs-based sensing strategy could be extensively applied to detect other analytes by anchoring the corresponding probes.
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