Journal
FOOD CHEMISTRY
Volume 367, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.130737
Keywords
Immunochromatographic assay; Metal-organic frameworks; AuNPs; Label strategy; Furazolidone
Funding
- National Science Foundation of China [21675127, 31972150]
- Shaanxi Provincial Science Fund for Distinguished Young Scholars [2018JC-011]
- Key Research and Development Plan of Shaanxi Province [2019NY-109]
- Key Industries Innovation Chain Project of Shaanxi Province [2019ZDLSF0708]
- Natural Science Foundation Project in Guangdong Provincial [2020A1515010778]
- Development Project of Qinghai Provincial Key Laboratory [2017-ZJ Y10]
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This study presents a nano-signal label strategy using zirconium MOFs and gold nanoparticles to construct powerful matrix materials, showing excellent biocompatibility and bright signal labels in immunochromatographic assay.
Creating universal signal labels from fundamental building blocks with excellent biocompatibility and wellcontrolled size/uniformity simultaneously for immunochromatographic assay (ICA) is highly desired but extremely challenging. Here, a nano-signal label strategy was reported, in which the amino-terminated zirconium MOFs (NU66) are adopted to construct powerful matrix materials and gold nanoparticles (AuNPs) act as the linker between metal-organic frameworks (MOFs) and antibodies. Particularly, AuNPs were immobilized directly on the surface of NU66, giving NU66 excellent biocompatibility with bright color signal labels and improving the salt ion stability of AuNPs. As a proof of concept, the furazolidone residues was monitored by the developed NU66@AuNPs-ICA in food samples (pork, shrimp and eggs). With 3-[(4-carboxyphenyl) monomethyl] amino-2oxazolidinone (CPAOZ) as analyte target, the visual limit of detection (vLOD) and cut-off level were 0.6 ng/mL and 3.0 ng/mL, respectively. This work may open a new avenue for the application of MOFs in immunochromatography assays.
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