Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 156, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112438
Keywords
Aflatoxin B1; Bacillus amyloliquefaciens B10; Intestinal flora; Tight junction protein
Categories
Funding
- National Key Research and Devel-opment Program of China [2017YFC1600304]
- National Natural Science Foundation of China [31772809, 31972746, 31872538]
- Liaoning Provincial Natural Fund Guidance Program Project [2019-ZD-0708]
- China Postdoctoral Science Foundation [2016T90477]
- PAPD [UHK VT2019-2021]
Ask authors/readers for more resources
The study showed that Bacillus amyloliquefaciens B10 significantly improved body weight and intestinal inflammation in mice induced by Aflatoxin B1, and alleviated cecal inflammation by regulating intestinal flora.
Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus amyloliquefaciens B10 could significantly improve the effects of AFB1 on body weight and intestinal inflammation of mice and enhance the expression of tight-junction protein. Compared with the CON group, the combination of AFB1 and B10 significantly increased the abundance of Actinobacteria and Bacilli in a collaborative manner, and significantly reduced the abundance of Ruminococcae, Lactobacillaceae and Clostridia. Meanwhile, the results showed that the abundance of Bacterides and Bacterdia in AFB1 + B10 group was significantly lower than that of AFB1 group, and the Firmicutes increased significantly. Bacillus amyloliquefaciens B10 can be used as a feed additive and alleviate cecal inflammation induced by AFB1 in mice by regulating intestinal flora.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available