Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 156, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112435
Keywords
Bisphenol-A; Ovary; Zebrafish; Proteomic; Proteostasis
Categories
Funding
- Spanish Junta de Andalucia [P09-AGR-5143]
- University College Cork (UCC) , Cork, Ireland
- Genomic Service from the Central Services for Research of the University of Cordoba (SCAI)
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The study suggests that short-term exposure to low concentrations of BPA can have effects on ovarian follicular development in zebrafish at both histopathological and proteomic levels. Even inadvertent exposure to small amounts of BPA could lead to alterations in essential biological processes.
Human exposure to bisphenol-A (BPA) is largely unavoidable because BPA is an environmental contaminant found in soil, water, food and indoor dust. The safety of authorized BPA amounts in consumer products is under question because new studies have reported adverse effects of BPA at doses far below that previously established by the NOAEL (50 mu g/kg per day). To protect public health, the consequences of low-dose BPA exposure in different organs and organismal functions must be further studied to generate relevant data. This study attempted to investigate the effects and potential molecular mechanisms of short-term exposure to 1 mu g/L BPA on zebrafish ovarian follicular development. We observed only minor changes at the histopathological level with a small (3 %) increase in follicular atresia. However, a shotgun proteomics approach indicated deep alterations in BPA-exposed ovarian cells, including induction of the oxidative stress response, metabolic shifts and degradome perturbations, which could drive oocytes towards premature maturation. Based on these results, it could be suggested that inadvertent exposure to small concentrations of BPA on a continuous basis causes alteration in biological processes that are essential for healthy reproduction.
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