Journal
FERTILITY AND STERILITY
Volume 116, Issue 6, Pages 1432-1435Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2021.10.023
Keywords
ART; definition; embryo implantation; recurrent implantation failure
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Funding
- Eunice Kennedy Shriver National Institute for Child Health and Development (NICHD) [P01HD106485]
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Recurrent implantation failure (RIF) is a clinical scenario where patients fail to achieve pregnancy after multiple embryo transfers. Studying RIF is challenging due to the diverse causes and definitions of implantation failure, but recent research suggests a personalized approach may be beneficial.
Recurrent implantation failure (RIF) is a poorly defined clinical scenario marked by failure to achieve pregnancy after multiple embryo transfers. The causes and definitions of implantation failure are heterogeneous, posing limitations on study design as well as the interpretation and application of findings. Recent studies suggest a novel, personalized approach to defining RIF. Here, we review the implantation physiology and definitions of the implantation rate, failure, and RIF. (C) 2021 by American Society for Reproductive Medicine.
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