4.6 Article

A guide to adhesion GPCR research

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

Yujing Sun et al.

Summary: ADGRG2, a critical regulator of male fertility, can be activated by a specific peptide p15. By using mutation and optimization techniques, a high affinity agonist for ADGRG2 was obtained. Characterization of key residues further elucidated the signaling mechanisms of ADGRG2 activation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

Gerti Beliu et al.

Summary: The study demonstrates the existence of intact aGPCR heterodimers in mammals, where the core TA region becomes unmasked in the cleaved GAIN domain, and intra-GAIN domain movements regulate the level of tethered agonist exposure, potentially controlling aGPCR activity.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex

Yu-Qi Ping et al.

Summary: This study reveals how glucocorticoid stress hormones activate adhesion GPCR G3 and how glucocorticoids bind to its transmembrane domain, triggering receptor activation. The research also found that GPR97's cytoplasmic side has an open cavity where interactions with the Go protein contribute to its high basal activity.

NATURE (2021)

Article Immunology

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Kuan-Yu I et al.

Summary: The study demonstrates that EMR2-mediated signaling is critical for triggering the activation signal for the NLRP3 inflammasome in both THP-1 monocytic cell line and primary monocytes. Stimulation of EMR2 by its agonistic 2A1 monoclonal antibody activates a G alpha(16)-dependent PLC-beta pathway, leading to downstream Akt, MAPK, NF-kappa B, and Ca2+ mobilization, eventually resulting in K+ efflux. These findings suggest that EMR2 and its associated signaling intermediates may serve as potential targets for intervention in NLRP3 inflammasome activation in inflammatory disorders.

FRONTIERS IN IMMUNOLOGY (2021)

Article Hematology

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation

Antonio Maglitto et al.

Summary: Studies have revealed the role of Gpr56 in stem cell generation and differentiation, with its knockout leading to bias towards myeloid differentiation in mouse embryo HSCs, and an increased definitive myeloid progenitor cell frequency in Gpr56(KO) ESC cultures. Furthermore, mouse Gpr97 is able to rescue Gpr56 deficiency in hematopoietic generation in zebrafish.

BLOOD ADVANCES (2021)

Article Cell Biology

The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo

Cheng-Chih Hsiao et al.

Summary: An inhibitory receptor GPR56 is specifically acquired by tissue-resident memory T (T-RM) cells during acute infection, but its impact on regulating effector functions of T-RM cells seems to be dispensable. The expression of GPR56 on T-RM cells is upregulated by the cytokine TGF-beta and the transcription factor Hobit.

CELLS (2021)

Article Biochemistry & Molecular Biology

Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling

Joshua D. Frenster et al.

Summary: The GPR133 receptor is cleaved shortly after protein synthesis, leading to increased canonical signaling. The dissociation of NTF and CTF at the plasma membrane promotes GPR133 activation and downstream signaling.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Cell & Tissue Engineering

Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK

Choon-Soo Lee et al.

Summary: Study identified the cardiomyogenic cell-surface marker LPHN2 as selectively expressed in cardiac progenitor cells and cardiomyocytes during differentiation, and demonstrated that cell sorting with an anti-LPHN2 antibody can promote isolation of these cell populations. It was shown that LPHN2-dependent phosphorylation plays a key role in regulating downstream molecules such as CDK5, Src, and P38MAPK, providing insights into the molecular mechanisms of cardiac differentiation.

STEM CELL REPORTS (2021)

Review Biochemistry & Molecular Biology

Emerging roles of adhesion G protein-coupled receptors

Matthew Rosa et al.

Summary: Adhesion G protein-coupled receptors (aGPCRs) form a subgroup within the GPCR superfamily with a unique structure and activation mechanism. Previous research has focused on aGPCR-ligand interactions to unravel the mysteries of this receptor family. Recent advancements have revealed a conserved method of aGPCR activation involving a tethered ligand within the GAIN domain.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Biochemistry & Molecular Biology

Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells

Robert J. Hall et al.

Summary: GPR126 is an adhesion G protein-coupled receptor associated with lung function and COPD, with identified SNPs affecting its function/expression. Activation of GPR126 in airway cells leads to downstream gene/pathway alterations, suggesting a role in airway remodeling. Further research is warranted to elucidate the exact mechanisms involved.

FASEB JOURNAL (2021)

Article Biochemistry & Molecular Biology

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer

Noor Mazin Abdulkareem et al.

Summary: ADGRF1 overexpression in HER2+ breast cancer promotes tumorigenesis by interacting with G alpha s pathway, inhibiting cell cycle pathways and leading to cellular quiescence. Its high expression is associated with worse breast cancer-specific survival and overall survival.

FASEB JOURNAL (2021)

Article Multidisciplinary Sciences

Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks

Daniel T. Pederick et al.

Summary: The study reveals that in mice, the complementary expression of cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) guides the precise assembly of CA1-to-subiculum connections in the medial and lateral hippocampal networks. The repulsion and attraction mechanisms mediated by Lphn2 and Ten3 cooperate to control the target selection of CA1 axons. The assembly of parallel hippocampal networks follows a Ten3 -> Ten3, Lphn2 -> Lphn2 rule instructed by reciprocal repulsions.

SCIENCE (2021)

Article Multidisciplinary Sciences

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

Anastasia Georgiadi et al.

Summary: The FNDC4-GPR116, liver-white adipose tissue endocrine axis plays a crucial role in controlling glucose homeostasis, while disruption of sFNDC4-GPR116 axis is associated with severe metabolic dysfunction in obesity and diabetes. Furthermore, sFNDC4 promotes insulin signaling and glucose uptake in white adipocytes through direct binding to GPR116, leading to improved glucose tolerance and reduced inflammation in prediabetic mice.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

Daniel del Toro et al.

Article Multidisciplinary Sciences

Structural basis for adhesion G protein-coupled receptor Gpr126 function

Katherine Leon et al.

NATURE COMMUNICATIONS (2020)

Review Biotechnology & Applied Microbiology

A review of antibody-based therapeutics targeting G protein-coupled receptors: an update

Catherine J. Hutchings

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Article Endocrinology & Metabolism

The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance

Tomas Suchy et al.

INTERNATIONAL JOURNAL OF OBESITY (2020)

Article Biochemistry & Molecular Biology

The regulatory G protein signaling complex, G?5?R7, promotes glucose- and extracellular signal?stimulated insulin secretion

Qiang Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Oncology

The role of GPR110 in lung cancer progression

Benting Ma et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Article Multidisciplinary Sciences

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

Jennifer Yeung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biology

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

Bill X. Huang et al.

COMMUNICATIONS BIOLOGY (2020)

Article Multidisciplinary Sciences

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

Richard Sando et al.

SCIENCE (2019)

Review Pharmacology & Pharmacy

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

Christopher J. Folts et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Multidisciplinary Sciences

Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli

Gentian Musa et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Article Immunology

CD97 is a critical regulator of acute myeloid leukemia stem cell function

Gaelle H. Martin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

Genetic basis of functional variability in adhesion G protein-coupled receptors

Alexander Bernd Knierim et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development

Ethan C. Bradley et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Article Multidisciplinary Sciences

miR-27a/b is a posttranscriptional regulator of Gpr126 (Adgrg6)

Gentian Musa et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Review Cell & Tissue Engineering

The role of GPCRs in bone diseases and dysfunctions

Jian Luo et al.

BONE RESEARCH (2019)

Article Biochemistry & Molecular Biology

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse

Jingxian Li et al.

Article Biochemistry & Molecular Biology

Pharmacogenomics of GPCR Drug Targets

Alexander S. Hauser et al.

Article Oncology

Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?

Nicole Scholz

FRONTIERS IN ONCOLOGY (2018)

Article Respiratory System

Heritability and genome-wide association study of diffusing capacity of the lung

Natalie Terzikhan et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Article Multidisciplinary Sciences

A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1

Olha Nazarko et al.

ISCIENCE (2018)

Review Cell Biology

Adhesion GPCRs in Kidney Development and Disease

Salvador Cazorla-Vazquez et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Article Endocrinology & Metabolism

Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling

Nariman Balenga et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Activation of Adhesion G Protein-coupled Receptors AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES

Lilian M. Demberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biotechnology & Applied Microbiology

Trends in GPCR drug discovery: new agents, targets and indications

Alexander S. Hauser et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Multidisciplinary Sciences

Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations

Christina A. Eichstaedt et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling

Kari Brown et al.

JCI INSIGHT (2017)

Article Biochemistry & Molecular Biology

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

Ayush Kishore et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

Caroline Wilde et al.

FASEB JOURNAL (2016)

Article Endocrinology & Metabolism

Adhesion G Protein-Coupled Receptor G1 (ADGRG1/GPR56) and Pancreatic β-Cell Function

Pontus Duner et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Review Neurosciences

Adhesion G protein-coupled receptors in nervous system development and disease

Tobias Langenhan et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Article Medicine, General & Internal

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

Steven E. Boyden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Super-complexes of adhesion GPCRs and neural guidance receptors

Verity A. Jackson et al.

NATURE COMMUNICATIONS (2016)

Editorial Material Oncology

BAI1: from cancer to neurological disease

Dan Zhu et al.

ONCOTARGET (2016)

Article Pharmacology & Pharmacy

Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist

Hannah M. Stoveken et al.

MOLECULAR PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

Lilian M. Demberg et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Behavioral Sciences

LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study

E. M. Bruxel et al.

GENES BRAIN AND BEHAVIOR (2015)

Article Medicine, Research & Experimental

BAI1 regulates spatial learning and synaptic plasticity in the hippocampus

Dan Zhu et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

Hannah M. Stoveken et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

Yue C. Lu et al.

STRUCTURE (2015)

Article Biochemistry & Molecular Biology

Structural Basis of Latrophilin-FLRT Interaction

Verity A. Jackson et al.

STRUCTURE (2015)

Article Gastroenterology & Hepatology

CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway

Chao Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

Stefanie Giera et al.

Nature Communications (2015)

Article Multidisciplinary Sciences

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

Sarah D. Ackerman et al.

Nature Communications (2015)

Article Cell Biology

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

Ekaterina Posokhova et al.

CELL REPORTS (2015)

Article Cell Biology

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

Nicole Scholz et al.

CELL REPORTS (2015)

Review Pharmacology & Pharmacy

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors

Joerg Hamann et al.

PHARMACOLOGICAL REVIEWS (2015)

Article Biochemistry & Molecular Biology

Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins REGULATION BY ALTERNATIVE SPLICING

Antony A. Boucard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

GPR126 Protein Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Receptor Signaling

Hengxiang Cui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Identification of Novel CELSR1 Mutations in Spina Bifida

Yunping Lei et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

A dual role for planar cell polarity genes in ciliated cells

Camille Boutin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

Kevin J. Paavola et al.

SCIENCE SIGNALING (2014)

Article Biochemistry & Molecular Biology

Orphan G Protein-Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size

James P. Bridges et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D

Taku Fukuzawa et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

Chinmoy Patra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Sticky Signaling-Adhesion Class G Protein-Coupled Receptors Take the Stage

Tobias Langenhan et al.

SCIENCE SIGNALING (2013)

Article Developmental Biology

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

Redouane Allache et al.

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY (2012)

Article Biochemistry & Molecular Biology

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

Tamako Nishimura et al.

Article Biochemistry & Molecular Biology

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

Demet Arac et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Signaling property study of adhesion G-protein-coupled receptors

Jamila Gupte et al.

FEBS LETTERS (2012)

Article Biochemistry & Molecular Biology

High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex

Antony A. Boucard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Immunology

Thy-1 (CD90) Is an Interacting Partner for CD97 on Activated Endothelial Cells

Elke Wandel et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD

M. Jain et al.

MOLECULAR PSYCHIATRY (2012)

Article Multidisciplinary Sciences

Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking ELTD1

Jinfeng Xiao et al.

PLOS ONE (2012)

Article Immunology

F4/80 and the related adhesion-GPCRs

Siamon Gordon et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Cell Adhesion Receptor GPR133 Couples to Gs Protein

Jens Bohnekamp et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

Kevin J. Paavola et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

Specific expression of GPR56 by human cytotoxic lymphocytes

Yen-Ming Peng et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2011)

Article Clinical Neurology

A Novel GPR56 Mutation Causes Bilateral Frontoparietal Polymicrogyria

Rong Luo et al.

PEDIATRIC NEUROLOGY (2011)

Article Multidisciplinary Sciences

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

John-Paul Silva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

Rong Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Anatomy & Morphology

GPR56 Is Essential for Testis Development and Male Fertility in Mice

Guangchun Chen et al.

DEVELOPMENTAL DYNAMICS (2010)

Article Biochemistry & Molecular Biology

Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing

Daisuke Okajima et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2010)

Article Multidisciplinary Sciences

The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse

Helen Waller-Evans et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

Frank Kuhnert et al.

SCIENCE (2010)

Article Cell Biology

News from the Brain: The GPR124 Orphan Receptor Directs Brain-Specific Angiogenesis

Elisabetta Dejana et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Multidisciplinary Sciences

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

Kelly R. Monk et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

Simon Yona et al.

FASEB JOURNAL (2008)

Article Biochemistry & Molecular Biology

Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a Gα12/13 and rho pathway

Tokuichi Iguchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Adhesion-GPCRs: emerging roles for novel receptors

Simon Yona et al.

TRENDS IN BIOCHEMICAL SCIENCES (2008)

Article Immunology

EMR1, the human homolog of F4/80, is an eosinophil-specific receptor

Jorg Hamann et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Review Biochemistry & Molecular Biology

The Adhesion GPCRs:: A unique family of G protein-coupled receptors with important roles in both central and peripheral tissues

T. K. Bjarnadottir et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Cell Biology

The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes

Mourad Matmati et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Biochemistry & Molecular Biology

An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2

Mark J. Kwakkenbos et al.

FASEB JOURNAL (2006)

Article Multidisciplinary Sciences

GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis

Lei Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biotechnology & Applied Microbiology

Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE

Irina Caminschi et al.

DNA SEQUENCE (2006)

Article Neurosciences

Protocadherin Celsr3 is crucial in axonal tract development

F Tissir et al.

NATURE NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion

S Shashidhar et al.

ONCOGENE (2005)

Meeting Abstract Rheumatology

Altered composition of CD97 splice variants in rheumatoid synovial tissue

F. A. van Gaalen et al.

ARTHRITIS RESEARCH & THERAPY (2005)

Article Multidisciplinary Sciences

G protein-coupled receptor-dependent development of human frontal cortex

XH Piao et al.

SCIENCE (2004)

Article Genetics & Heredity

Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II

MD Weston et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2004)

Article Biochemistry & Molecular Biology

Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility

B Davies et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif

HH Lin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biotechnology & Applied Microbiology

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors

TK Bjarnadóttir et al.

GENOMICS (2004)

Article Immunology

Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence

J Hamann et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

Article Biochemistry & Molecular Biology

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini

R Fredriksson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Cell Biology

Tissue distribution of the human CD97 EGF-TM7 receptor

LH Jaspars et al.

TISSUE ANTIGENS (2001)