Journal
FASEB JOURNAL
Volume 36, Issue 1, Pages -Publisher
WILEY
DOI: 10.1096/fj.202101199R
Keywords
cGAS; colorectal cancer; esophageal cancer; gastric cancer; gastrointestinal inflammatory disease; STING
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The cGAS-STING signaling pathway plays a crucial role in GI inflammatory diseases and cancers. Understanding the function and mechanism of this pathway is helpful for developing therapeutic strategies.
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has emerged as a key DNA-sensing machinery in innate immunity. Activation of cGAS-STING signaling pathway mediates the production of interferons and proinflammatory cytokines. Although cGAS-STING signaling pathway shows critical function in the maintenance of gut homeostasis, overactive cGAS-STING signaling pathway leads to gastrointestinal (GI) inflammation. Harnessing the effect and mechanism of the cGAS-STING signaling pathway could be beneficial for the development of novel strategies for the treatment of GI diseases. This review presents recent advances regarding the role of cGAS-STING signaling pathway in GI inflammatory disease and cancers and describes perspective therapeutic strategies targeting the signaling pathway.
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