4.7 Article

Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome-like phenotypes in prenatally androgenized female mice

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Characterization on gut microbiome of PCOS rats and its further design by shifts in high-fat diet and dihydrotestosterone induction in PCOS rats

Yanhua Zheng et al.

Summary: The study found that DHT and high-fat diet can lower the diversity of gut microbial community, shaping the association between gut microbiota and the development and pathology of PCOS.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2021)

Article Gastroenterology & Hepatology

Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis

Julien Pujo et al.

Summary: In this study, it was found that a probiotic strain contained increased levels of 3-hydroxyoctadecaenoic acid (C18-3OH), which was shown to decrease colitis in mice and was associated with anti-inflammatory properties of prebiotic fructooligosaccharides (FOS). The concentration of C18-3OH was correlated with an increase in specific bacterial genera in the microbiota. This suggests that C18-3OH production by bacteria could play a role in the anti-inflammatory properties of probiotics and in microbiota/host interactions.
Article Developmental Biology

Induction of aryl hydrocarbon receptor in granulosa cells endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome

Chisato Kunitomi et al.

Summary: Recent studies have highlighted the important role of aryl hydrocarbon receptor (AHR) in diseases such as obesity and cancer, beyond its known role as a receptor for endocrine-disrupting chemicals (EDCs). The activation of endoplasmic reticulum (ER) stress in granulosa cells is found to contribute to the pathology of polycystic ovary syndrome (PCOS) by upregulating AHR and its downstream signaling, particularly the AHR target gene cytochrome P450 IBI (CYPIBI). Inhibiting AHR activity with an antagonist shows promise in restoring normal ovarian function in PCOS mice.

MOLECULAR HUMAN REPRODUCTION (2021)

Article Biochemistry & Molecular Biology

Maternal adiponectin prevents visceral adiposity and adipocyte hypertrophy in prenatal androgenized female mice

Yanling Wu et al.

Summary: The study demonstrates that elevated levels of adiponectin in utero can improve insulin sensitivity, reduce body weight and fat mass gain in adult offspring, and protect against PNA-induced visceral adiposity in the offspring.

FASEB JOURNAL (2021)

Review Endocrinology & Metabolism

Intersection of Polycystic Ovary Syndrome and the Gut Microbiome

Maryan G. Rizk et al.

Summary: The etiology of polycystic ovary syndrome (PCOS) is still unclear, but studies suggest that dysbiosis of the gut microbiome may be a causative factor for metabolic and reproductive manifestations of PCOS. Changes in gut bacteria composition have been associated with PCOS, indicating a potential therapeutic target for the syndrome.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

Review Developmental Biology

Mechanisms of intergenerational transmission of polycystic ovary syndrome

Daniel A. Dumesic et al.

REPRODUCTION (2020)

Article Endocrinology & Metabolism

Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota

Beza Jobira et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Pharmacology & Pharmacy

Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity - a preliminary report

Yuanjiao Liang et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

Article Gastroenterology & Hepatology

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes

Cristina Menni et al.

GUT MICROBES (2020)

Review Gastroenterology & Hepatology

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Mary Ellen Sanders et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Sex, Microbes, and Polycystic Ovary Syndrome

Varykina G. Thackray

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Biochemistry & Molecular Biology

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

Sanjiv Risal et al.

NATURE MEDICINE (2019)

Review Neurosciences

Microbiome changes: an indicator of Parkinson's disease?

Caroline Haikal et al.

TRANSLATIONAL NEURODEGENERATION (2019)

Article Endocrinology & Metabolism

Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism

Pedro J. Torres et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Endocrinology & Metabolism

Gut Microbiota and the Polycystic Ovary Syndrome: Influence of Sex, Sex Hormones, and Obesity

Maria Insenser et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Review Endocrinology & Metabolism

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

Hector F. Escobar-Morreale

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Reproductive and Behavior Dysfunction Induced by Maternal Androgen Exposure and Obesity Is Likely Not Gut Microbiome-Mediated

Lisa Lindheim et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2018)

Review Microbiology

Roseburia spp.: a marker of health?

Zohreh Tamanai-Shacoori et al.

FUTURE MICROBIOLOGY (2017)

Review Obstetrics & Gynecology

Is foetal hyperexposure to androgens a cause of PCOS?

Panagiota Filippou et al.

HUMAN REPRODUCTION UPDATE (2017)

Article Multidisciplinary Sciences

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model

Anna Benrick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Microbiology

The mouse gut microbiome revisited: From complex diversity to model ecosystems

Thomas Clavel et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2016)

Review Multidisciplinary Sciences

Diet-microbiota interactions as moderators of human metabolism

Justin L. Sonnenburg et al.

NATURE (2016)

Article Multidisciplinary Sciences

The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome

Scott T. Kelley et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

Association between Polycystic Ovary Syndrome and Gut Microbiota

Yanjie Guo et al.

PLOS ONE (2016)

Article Obstetrics & Gynecology

Placental steroidogenesis in pregnant women with polycystic ovary syndrome

Manuel Maliqueo et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2013)

Article Endocrinology & Metabolism

Prenatal androgen excess programs metabolic derangements in pubertal female rats

Xiaonan Yan et al.

JOURNAL OF ENDOCRINOLOGY (2013)

Editorial Material Multidisciplinary Sciences

Welcome to the Microgenderome

Magdalena B. Flak et al.

SCIENCE (2013)

Review Multidisciplinary Sciences

Functional interactions between the gut microbiota and host metabolism

Valentina Tremaroli et al.

NATURE (2012)

Article Multidisciplinary Sciences

Human gut microbiome viewed across age and geography

Tanya Yatsunenko et al.

NATURE (2012)

Article Endocrinology & Metabolism

Endocrine Traits of Polycystic Ovary Syndrome in Prenatally Androgenized Female Sprague-Dawley Rats

Xiao-Yan Wu et al.

ENDOCRINE JOURNAL (2010)

Article Endocrinology & Metabolism

Prenatal androgen exposure programs metabolic dysfunction in female mice

Alison V. Roland et al.

JOURNAL OF ENDOCRINOLOGY (2010)

Article Multidisciplinary Sciences

Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: Implications for a common fertility disorder

SD Sullivan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)