4.5 Review

Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward

Related references

Note: Only part of the references are listed.
Article Neurosciences

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies

Kenji Tagai et al.

Summary: A panel of radiochemicals for in vivo PET imaging of tau pathologies in AD has been developed, but sensitive detection of FTLD tau inclusions remains challenging. The imaging probe PM-PBB3 successfully captures diverse tau deposits in AD and FTLD, with increased binding observed in diseased patients in a subsequent clinical PET study. Visual inspection of F-18-PM-PBB3-PET images aids in individually based identification of diverse clinical phenotypes of FTLD on a neuropathological basis.

NEURON (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework

Gerard N. Bischof et al.

Summary: The validation of second-generation tau PET tracers has passed the analytical phase of the strategic biomarker roadmap, with studies showing evidence of superiority over first-generation tracers. However, research on clinical validity is still ongoing.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Article Multidisciplinary Sciences

Structure-based classification of tauopathies

Yang Shi et al.

Summary: The structures of tau filaments from different tauopathies vary, allowing for a hierarchical classification of these diseases. Some tauopathies share similar filament folds, while others have distinct folding patterns.

NATURE (2021)

Review Biochemistry & Molecular Biology

PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology

Valentin Duclos et al.

Summary: PET/CT molecular imaging has been widely used in clinical practice, driven by quantification and radiolabeled molecular probe vectorization. Despite efforts to standardize image analysis internationally, advanced metrics are still used in practice. The integration of PET imaging with radionuclide therapy has paved the way for highly sensitive radionuclide-based precision medicine research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Immunology

PET Imaging of Neuroinflammation in Alzheimer's Disease

Rong Zhou et al.

Summary: Neuroinflammation plays a significant role in the pathogenesis of Alzheimer's disease, and molecular imaging techniques have provided valuable insights into its involvement in disease progression. The development of new generation translocator protein tracers and other imaging technologies offers promise for monitoring disease progression and identifying potential targets for future research.

FRONTIERS IN IMMUNOLOGY (2021)

Review Neurosciences

Recent Preclinical Insights Into the Treatment of Chronic Traumatic Encephalopathy

Patrick W. Breen et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging

N. Arul Murugan et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

Article Multidisciplinary Sciences

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Benjamin Falcon et al.

NATURE (2019)

Article Medicine, General & Internal

Tau Positron-Emission Tomography in Former National Football League Players

Robert A. Stern et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Clinical Neurology

Tau Imaging in Neurodegenerative Diseases Using Positron Emission Tomography

Yi Ting Wang et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

Review Clinical Neurology

Management of chronic traumatic encephalopathy

Robert Cantu et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2019)

Article Neurosciences

[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series

Marta Marquie et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Tau PET imaging in neurodegenerative tauopathies-still a challenge

Antoine Leuzy et al.

MOLECULAR PSYCHIATRY (2019)

Article Clinical Neurology

Chronic traumatic encephalopathy - confusion and controversies

Douglas H. Smith et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Neuroimaging

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy

Orit H. Lesman-Segev et al.

NEUROIMAGE-CLINICAL (2019)

Article Medicine, General & Internal

Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau

Keith A. Josephs

MAYO CLINIC PROCEEDINGS (2017)

Article Multidisciplinary Sciences

Cryo-EM structures of tau filaments from Alzheimer's disease

Anthony W. P. Fitzpatrick et al.

NATURE (2017)

Article Clinical Neurology

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Kok Pin Ng et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Biochemistry & Molecular Biology

Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy

Jeong-Sun Seo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?

Lucy Vivash et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

Article Neurosciences

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

Jonathan D. Cherry et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Clinical Neurology

The Neuropathology of Chronic Traumatic Encephalopathy

Ann C. McKee et al.

BRAIN PATHOLOGY (2015)

Article Neurosciences

Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study

Jennifer M. Coughlin et al.

NEUROBIOLOGY OF DISEASE (2015)

Article Multidisciplinary Sciences

In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging

Jorge R. Barrio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Biochemistry & Molecular Biology

SPECT and PET Serve as Molecular Imaging Techniques and in Vivo Biomarkers for Brain Metastases

Barbara Palumbo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Geriatrics & Gerontology

PET Scanning of Brain Tau in Retired National Football League Players: Preliminary Findings

Gary W. Small et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2013)

Article Clinical Neurology

The spectrum of disease in chronic traumatic encephalopathy

Ann C. McKee et al.

BRAIN (2013)

Article Endocrinology & Metabolism

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

David R. Owen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Geriatrics & Gerontology

Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults

Linda M. Ercoli et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression

Yilong Cui et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

11C-DPA-713:: A novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

Herve Boutin et al.

JOURNAL OF NUCLEAR MEDICINE (2007)

Article Clinical Neurology

Chronic traumatic encephalopathy in a National Football League player

BI Omalu et al.

NEUROSURGERY (2005)

Review Geriatrics & Gerontology

The molecular genetics of the tauopathies

M van Slegtenhorst et al.

EXPERIMENTAL GERONTOLOGY (2000)