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COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2022)

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Summary: Preliminary findings suggest a relationship between lower serum 25-hydroxyvitamin D levels and COVID-19 incidence and severity. In this study, patients with hypovitaminosis D upon admission showed worse clinical outcomes, with higher levels of inflammatory and coagulation markers. Lower vitamin D status at admission was significantly associated with increased risk of in-hospital mortality in COVID-19 patients, highlighting its potential as a modifiable risk factor.

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Summary: The study evaluated patients with confirmed COVID-19 between March and June 2020, finding a higher proportion of low vitamin-D levels in ICU patients, with an association to younger age and higher viral loads. However, there were no significant differences in clinical outcomes between patients with low and normal vitamin-D levels. Further large scale randomized controlled trials are needed to explore the relationship between vitamin-D levels and COVID-19 infection.

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被撤回的出版物: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease (Retracted article. See vol. 12, 2022)

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