Journal
EXPERT OPINION ON PHARMACOTHERAPY
Volume 23, Issue 3, Pages 387-403Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14656566.2021.1999413
Keywords
Cardiovascular events; gliclazide; glimepiride; glipizide; glycemic durability; hypoglycemia; sulfonylureas; type 2 diabetes
Categories
Funding
- Faculty of Medicine, Macau University of Science and Technology
Ask authors/readers for more resources
Type 2 diabetes is associated with increased risk for cardiovascular and renal disease. Sulfonylureas are potent glucose lowering drugs which can be used as second-line treatment for T2D, with some newer generation drugs showing less risk of hypoglycemia and comparable durability of glycemic control. Precision medicine may help refine the selection of T2D patients who may benefit more from sulfonylureas.
Introduction Type 2 diabetes (T2D) is increasingly prevalent and associated with increased risk for cardiovascular and renal disease. After lifestyle modification, metformin is usually the first-line pharmacotherapy and sulfonylureas are traditionally added after metformin failure. However, with newer glucose lowering drugs that may have less risk of hypoglycemia or that may reduce cardiovascular and renal events, the position of sulfonylureas is being reevaluated. Areas covered In this article, the authors review relevant publications related to the use of sulfonylureas. Expert opinion Sulfonylureas are potent glucose lowering drugs. The risk of hypoglycemia varies with different drugs within the class and can be minimized by using the safer drugs, possibly in lower doses. Cardiovascular events do not appear to be increased with some of the newer generation drugs. The durability of glycemic control also appears comparable to other newer agents. Sulfonylureas are the preferred treatment for some types of monogenic diabetes and selection of T2D patients who may have greater benefit from sulfonylureas based on certain phenotypes and genotypes is likely to be refined further by precision medicine. Sulfonylureas are inexpensive and readily available everywhere and they are still the most frequently used second-line treatment for T2D in many parts of the world.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available