Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 19, Issue 2, Pages 133-146Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2034784
Keywords
Delivery; endoplasmic reticulum; lysosomes; mitochondria; nuclei; organelle; precision medicine; targeting
Categories
Funding
- Swedish Research Council (VR-NT)
- Estonian Ministry of Education and Research [IUT20-26]
- EU [2014-2020.4.01.15-0013]
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This review provides an overview of CPP technologies for intracellular organelle targeting, discussing their pharmacological and therapeutical applications. Targeted drug delivery to specific organelles offers improved efficacy, control of mode of action, and potential to overcome drug resistance mechanisms.
Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to address drug delivery to specific intracellular compartments by covalent conjugation to targeting sequences, potentially enabling strategies to combat most diseases. Areas covered This updated review article provides an overview of current intracellular organelle targeting by CPP. The targeting strategies of CPP and CPP/cargo complexes to specific cells or intracellular organelles are summarized, and the review provides an update on the current data for their pharmacological and therapeutical applications. Expert opinion Targeted drug delivery is moving from the level of tissue or specific pathogenic cell to the level of specific organelle that is the target of the drug, an important aspect in drug design and development. Organelle-targeted drug delivery results in improved efficacy, ability to control mode of action, reduction of undesired toxicities and side effects, and the possibility to overcome drug resistance mechanisms.
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