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Opportunities in combinational chemo-immunotherapy for breast cancer using nanotechnology: an emerging landscape

Journal

EXPERT OPINION ON DRUG DELIVERY
Volume 19, Issue 3, Pages 247-268

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2044785

Keywords

Anticancer vaccines; breast carcinoma; checkpoint blocker; cytokines; liposomes; monoclonal antibodies

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Breast carcinoma is a leading cause of cancer-related death in women due to poor response to traditional therapies. Combining chemotherapy and immunotherapy has been introduced to overcome challenges such as cytotoxicity and drug resistance. Nanotechnology-based drug delivery systems show promise in targeted and controlled drug release for more effective treatment.
Introduction Breast carcinoma (BC) is one of the most frequent causes of cancer-related death among women, which is due to the poor response to conventional therapy. There are several complications associated with monotherapy for cancer, such as cytotoxicity to normal cells, multidrug resistance (MDR), side effects, and limited applications. To overcome these challenges, a combination of chemotherapy and immunotherapy (monoclonal antibodies, anticancer vaccines, checkpoint inhibitors, and cytokines) has been introduced. Drug delivery systems (DDSs) based on nanotechnology have more applications in BC treatment owing to their controlled and targeted drug release with lower toxicity and reduced adverse drug effects. Several nanocarriers, such as liposomes, nanoparticles, dendrimers, and micelles, have been used for the effective delivery of drugs. Areas covered This article presents opportunities and challenges in BC treatment, the rationale for cancer immunotherapy, and several combinational approaches with their applications for BC treatment. Expert opinion Nanotechnology can be used for the early prognosis and cure of BC. Several novel and targeted DDSs have been developed to enhance the efficacy of anticancer drugs. This article aims to understand new strategies for the treatment of BC and the appropriate design of nanocarriers used as a combinational DDS.

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