Journal
EXPERIMENTAL NEUROLOGY
Volume 344, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2021.113809
Keywords
Levo-tetrahydropalmatine; Methamphetamine; Addiction; Neurotoxicity; Behavioral sensitization; Conditioned place preference
Categories
Funding
- National Natural Science Foundation of China [81973404, 81503058]
- Department of Education of Liaoning Province [JC2019034]
- Natural Science Foundation of Liaoning Province [2014021065]
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METH leads to compulsive drug-seeking and drug-taking behavior, resulting in addiction and neurotoxicity; L-THP has inhibitory effects on the occurrence, maintenance, and relapse of METH addiction; L-THP can enhance nerve cell plasticity and improve nerve cell function through brain-derived neurotrophic factor pathways.
Levo-tetrahydropalmatine (l-THP) is mainly derived from the dried tuber of the Papaveraceae plant Corydalis, also called Corydalis B, which is a drug with analgesic, hypnotic, sedative and other effects. Methamphetamine (METH) belongs to the central nervous stimulant and is a highly addictive drug. It is an urgent problem to study the mechanism of methamphetamine neurotoxicity and to search for the therapeutic targets of the METH addiction. This review is aimed to discuss the pharmacological mechanism and the protective effects of l-THP on METH-induced neurotoxicity, and to explore the therapeutic prospects of l-THP for METH addiction to provide an innovative application of l-THP in clinic. It was found that exposure to METH leads to the compulsive drugseeking and drug-taking behavior, which is ultimately resulted in METH addiction and neurotoxicity. L-THP has the inhibitory effects on the incidence, maintenance and relapse of METH addiction. L-THP can effectively enhance the plasticity of nerve cells and improve the function of nerve cells where brain-derived neurotrophic factor (BDNF) and its pathways play a protective role. Therefore, l-THP has the potential to become an important therapeutic drug for METH addiction and neurotoxicity.
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