Journal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
Volume 122, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2021.104678
Keywords
Stem cell factor; CD117; Immunohistochemistry; C-kit
Categories
Funding
- National Cancer Institute at the National Institutes of Health [R00 CA175291]
- NIH/NCATS Grant [UL1 TR001420]
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Stem cell factor (SCF) plays a crucial role in development, with continued expression in many cell types and tissues in adult humans and mice. High SCF expression in certain organs may be linked to an increased risk of SCF/CD117-related diseases.
Stem cell factor (SCF) is an essential cytokine during development and is necessary for gametogenesis, hematopoiesis, mast cell development, stem cell function, and melanogenesis. Here, we measure SCF concentration and distribution in adult humans and mice using gene expression analysis, tissue staining, and organ protein lysates. We demonstrate continued SCF expression in many cell types and tissues into adulthood. Tissues with high expression in adult humans included stomach, spleen, kidney, lung, and pancreas. In mice, we found high SCF expression in the esophagus, ovary, uterus, kidney, and small intestine. Future studies may correlate our findings of increased, organ-specific SCF concentrations within adult tissues with increased risk of SCF/CD117related disease.
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