Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19

Precipitated by chronic psychological stress, immune system dysregulation, and a hyperinflammatory state, the sequelae of postacute COVID-19 (long COVID) include depression and new-onset diabetes. We hypothesize that exercise counters the neuropsychiatric and endocrine sequelae of long COVID by inducing the release of circulating factors that mediate the anti-inflammatory response, support brain homeostasis, and increase insulin sensitivity.

Automated summary

This passage discusses the sequelae of long COVID-19, including depression and diabetes, and proposes the hypothesis that exercise can counter these sequelae by releasing circulating factors.