Journal
EUROSURVEILLANCE
Volume 27, Issue 2, Pages -Publisher
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2022.27.2.2101197
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Funding
- Health and Medical Research Fund [COVID190126, CID-HKU2, COVID19F05]
- Health and Medical Research Fund Research Fellowship Scheme [06200097]
- General Research Fund [17110020]
- Innovation and Technology Commission of the Government of the Hong Kong Special Administrative Region
- Enhanced New Staff Start-up Research Grant from LKS Faculty of Medicine, The University of Hong Kong
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This study observed the antibody levels in 850 fully vaccinated individuals in Hong Kong's COVID-19 vaccination program using ELISA and surrogate virus neutralization test. The results showed that the antibody levels remained above the positive cut-off values within the first 6 months. However, the antibody levels in the CoronaVac-vaccinated group started to decline below the cut-off values after 4 months.
The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong's COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The els remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group's (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination.
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