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Summary: The study analyzed antibody neutralization activity against a panel of authentic isolates and chimeric SARS-CoV-2 variants, showing significantly reduced neutralizing activity against the B.1.351 variant first identified in South Africa. Antibodies targeting the receptor-binding domain and N-terminal domain, monoclonal antibodies, convalescent sera, and mRNA vaccine-induced immune sera exhibited decreased inhibitory activity against viruses with an E484K spike mutation, suggesting a need for updated monoclonal antibodies or vaccine adjustments to prevent loss of protection against emerging variants.
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Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.
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Summary: Italy introduced a tiered system of COVID-19 control measures in November 2020. The study found that with the implementation of this tier system, human activities outside of residential settings decreased gradually, and the reproduction number of the virus decreased significantly, especially in the most restrictive red tier.
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Summary: The case of reinfection from distinct virus lineages in Brazil with the E484K mutation raises concerns about the duration of protective immune responses against SARS-CoV-2, especially with the variant associated with escape from neutralizing antibodies. This highlights potential challenges for virus control measures.
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