4.6 Editorial Material

IL-6 trans-signalling: how Haemophilus surfs the NET to amplify inflammation in COPD

Related references

Note: Only part of the references are listed.
Article Allergy

The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease

Alison J. Dicker et al.

Summary: The study found that the sputum microbiome of COPD patients is closely related to disease severity, frequent exacerbations, blood eosinophil levels, etc., and different dominant microbiomes have different impacts. The diversity of sputum microbiomes is closely related to the development and mortality of COPD.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Respiratory System

Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline

James D. Chalmers et al.

Summary: This guideline provides clear recommendations for the management of COVID-19 patients, including strong recommendations in favor of systemic corticosteroids and anticoagulation therapy, and conditional recommendations for IL-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in specific situations.

EUROPEAN RESPIRATORY JOURNAL (2021)

Article Critical Care Medicine

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

Holly R. Keir et al.

Summary: Bronchiectasis is a neutrophilic inflammatory disease, and research has shown that neutrophilic inflammation is associated with disease severity and treatment response. Studying the role of NETs in bronchiectasis can help develop new treatment strategies.

LANCET RESPIRATORY MEDICINE (2021)

Article Respiratory System

Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD

Sofia Winslow et al.

Summary: The study identified a subset of COPD patients with IL-6TS pathway activation, characterized by persistent neutrophilic inflammation, impaired respiratory function, and increased nitrite levels in lung tissue, suggesting that chronic colonization with Haemophilus may be a driving force for these patients.

EUROPEAN RESPIRATORY JOURNAL (2021)

Letter Respiratory System

Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study

Andrea Gramegna et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Article Respiratory System

Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis

Martina Oriano et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Article Medicine, General & Internal

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

James D. Chalmers et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Allergy

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Zala Jevnikar et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Respiratory System

Airway inflammation in COPD: progress to precision medicine

Christopher Brightling et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Critical Care Medicine

Pregnancy Zone Protein Is Associated with Airway Infection, Neutrophil Extracellular Trap Formation, and Disease Severity in Bronchiectasis

Simon Finch et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Respiratory System

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

Kylie B. R. Belchamber et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Letter Respiratory System

Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD

Aili L. Lazaar et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Article Biochemistry & Molecular Biology

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

Marie Toussaint et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens

Daniel M. L. Storisteanu et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

Article Respiratory System

Lung microbiome dynamics in COPD exacerbations

Zhang Wang et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Article Respiratory System

Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma

Pinja Ilmarinen et al.

EUROPEAN RESPIRATORY JOURNAL (2016)

Article Allergy

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Md Ashik Ullah et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Huw D. Lewis et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Critical Care Medicine

Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis-like Lung Disease

Stefanie Gehrig et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Review Biochemistry & Molecular Biology

The Neutrophil in Chronic Obstructive Pulmonary Disease Too Little, Too Late or Too Much, Too Soon?

Kim Hoenderdos et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Critical Care Medicine

Advances in neutrophil biology - Clinical implications

Andrew S. Cowburn et al.

CHEST (2008)

Review Pharmacology & Pharmacy

Therapy for chronic obstructive pulmonary disease in the 21st century

LE Donnelly et al.

DRUGS (2003)

Article Biochemistry & Molecular Biology

Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species

BM Fischer et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)