4.7 Article

Radiomics model based on shear-wave elastography in the assessment of axillary lymph node status in early-stage breast cancer

Journal

EUROPEAN RADIOLOGY
Volume 32, Issue 4, Pages 2313-2325

Publisher

SPRINGER
DOI: 10.1007/s00330-021-08330-w

Keywords

Breast cancer; Lymphatic metastasis; Shear-wave elastography; Radiomics; Nomogram

Funding

  1. China Postdoctoral Science Foundation [2020M682422]
  2. Wuhan Science and Technology Bureau [2017060201010181]
  3. Health Commission of Hubei Province [WJ2019M077, WJ2019H227]

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A radiomics nomogram based on ultrasound elastography was developed and validated for preoperative assessment of axillary lymph node status in early-stage breast cancer patients. The model showed favorable predictive ability and could provide incremental information for clinical decision-making.
Objectives To develop and validate an ultrasound elastography radiomics nomogram for preoperative evaluation of the axillary lymph node (ALN) burden in early-stage breast cancer. Methods Data of 303 patients from hospital #1 (training cohort) and 130 cases from hospital #2 (external validation cohort) between Jun 2016 and May 2019 were enrolled. Radiomics features were extracted from shear-wave elastography (SWE) and corresponding B-mode ultrasound (BMUS) images. The minimum redundancy maximum relevance and least absolute shrinkage and selection operator algorithms were used to select ALN status-related features. Proportional odds ordinal logistic regression was performed using the radiomics signature together with clinical data, and an ordinal nomogram was subsequently developed. We evaluated its performance using C-index and calibration. Results SWE signature, US-reported LN status, and molecular subtype were independent risk factors associated with ALN status. The nomogram based on these variables showed good discrimination in the training (overall C-index: 0.842; 95%CI, 0.773-0.879) and the validation set (overall C-index: 0.822; 95%CI, 0.765-0.838). For discriminating between disease-free axilla (N0) and any axillary metastasis (N + (>= 1)), it achieved a C-index of 0.845 (95%CI, 0.777-0.914) for the training cohort and 0.817 (95%CI, 0.769-0.865) for the validation cohort. The tool could also discriminate between low (N + (1-2)) and heavy metastatic ALN burden (N + (>= 3)), with a C-index of 0.827 (95%CI, 0.742-0.913) in the training cohort and 0.810 (95%CI, 0.755-0.864) in the validation cohort. Conclusion The radiomics model shows favourable predictive ability for ALN staging in patients with early-stage breast cancer, which could provide incremental information for decision-making.

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