Journal
EUROPEAN POLYMER JOURNAL
Volume 159, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2021.110733
Keywords
Bilayered nanofibrous membranes; Quaternized silicone; Scarless wound healing
Categories
Funding
- Key R&D Program of Shandong province [2019JZZY011104]
- technology project of Yantai [2018XSCC048, 2019XDHZ108]
- College Youth Innovation Science and Technology Support Program of Shandong province [2020KJK003]
- Initial Scientific Research Fund of Young Teachers in Binzhou Medical University [BY2021KYQD23]
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The bilayered nanofibrous membrane with good mechanical properties, antibacterial function, hydrophilicity, biocompatibility, and hemostasis is beneficial for wound healing. The outer layer provides mechanical support and antibacterial properties, while the inner layer promotes wound healing with hydrophilicity and biocompatibility. The membranes show excellent properties for wound dressing applications, accelerating wound healing and inhibiting scar formation.
The design of novel wound dressings with favorable mechanical properties, hemostasis, inherent antibacterial function, and biocompatibility to facilitate skin wound healing and inhibit scar formation has practical significance in clinical applications. Herein, a bilayered nanofibrous membrane (PQCQS) was fabricated by electrospinning poly(epsilon-caprolactone) (PCL)/quaternized silicone (PQS, outer layer) and polyvinyl alcohol/collagen/ quaternized chitosan (PCQC, inner layer) as wound dressings for damaged skin. The PQS nanofiber was utilized as the outer layer of the wound dressing because it combined the good mechanical property of PCL and antibacterial performance of quaternized silicone to suppress scar formation and provide a stable microenvironment for the wound healing process. The inner membrane (PCQC) exhibited hydrophilicity, biocompatibility, and hemostasis, thus facilitating wound healing. The PQCQS membranes exhibited excellent hydrophilicity, outstanding thermal stability, comparable mechanical properties with human skin, efficient hemostatic performance, and cytocompatibility. Moreover, the PQCQS membranes demonstrated a good balance between antibacterial activity and cell proliferation. Moreover, the PQCQS membranes significantly expedited the wound healing process and inhibited scar hyperplasia better than commercial ointment (MSSG and KELO-COTE) in a rabbit ear full-thickness wounds defect model. That is, the bilayered nanofibrous membranes, with excellent antibacterial activity, hydrophilicity, hemostatic performance, scar inhibition, and wound healing properties, are appropriate candidates for wound dressings.
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