Journal
EUROPEAN POLYMER JOURNAL
Volume 160, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2021.110767
Keywords
Biopolymer; Chitosan; Gene delivery; Mucoadhesion; Nanoparticles; Nasal; Pulmonary; Transdermal
Categories
Funding
- Gedeon Richter Ltd - GINOP project [2.2.1-15-2016-00007]
- Ministry of Human Capacities, Hungary grant, TKP-2020
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Chitosan, a natural biopolymer, is commonly used in drug delivery due to its biodegradability and biocompatibility. Its derivatives have been synthesized to enhance mucoadhesion and solubility, while nano and micro particles of chitosan have been reported to improve drug bioavailability. Chitosan has also shown promise in active targeted drug and gene delivery, thanks to its tunable surface modifications.
Chitosan (CS) is a natural biopolymer used frequently in drug delivery because of its biodegradability and biocompatibility. Several derivatives of CS have also been synthesized to improve the mucoadhesion and solubility of the nascent CS. The nano and micro particles are reported to have enhanced drug bioavailability, solubility and permeation. Recently, there is an advancement in the active targeted drug and gene delivery using CS because of its tunable surface modifications. This review focuses on CS and its chemically modified structures along with their different nanostructures with examples from the most exploited routes of administration. Herein, the functionalization of CS nanoparticles has also been enlisted along with the use of CS in the immunotherapy as vaccine carriers. Beside, few patents, ongoing clinical trials and already marketed CS-based products are also enlisted.
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